Pathway link MTORC1-TOPMRNA
mTORC1 5'TOP mRNA
mTORC1 activates 5'TOP mRNA.
When mTORC1 is on, the cell does not simply make more of every protein. It preferentially makes the parts of its own protein-making machinery, from a particular class of messages marked at one end.
The conditions it holds under
The selectivity is from ribosome profiling in cancer cell lines (HSI2012); the lifespan link is Drosophila only (WAN2026); PLEDGER2026 shows the same arm being repressed in chronically activated human CD8+ T cells. No human in vivo measurement of 5'TOP translation under an mTOR inhibitor in this corpus. Which of the 5'TOP transcripts matter for which phenotype is not resolved.
- Time it takes
- minutes
- Step
- indirect (through steps not drawn here)
- Measured in
- human cells, Drosophila
- Where in the cell
- cytosol
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | The translational landscape of mTOR signalling steers cancer initiation and metastasisHSI2012 Showed WHY mTOR-driven translation matters for cancer: in prostate cancer, oncogenic mTOR selectively translates a specific set of pro-invasion mRNAs that drive metastasis. An ATP-competitive mTOR inhibitor (INK128) reversed that signature - an early preclinical rationale from mouse models and cell lines, not a clinical result. |
| 2026 | A | Lsp2 links mTORC1 to TOP mRNA translation and lifespan in DrosophilaWAN2026 Identifies Lsp2, a Drosophila fat-body storage protein, as an amino-acid-induced feedback activator of mTORC1 that specifically boosts translation of TOP-motif mRNAs (mostly ribosomal proteins) via 4E-BP — a rapamycin-resistant arm of mTORC1 output. Genetic loss of Lsp2 reduces TOP mRNA translation and robustly extends lifespan without cost to reproduction, revealing a rapamycin-independent route from mTORC1 activity to organismal longevity. |
| 2026 | M | Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells in vitro.PLEDGER2026 Ribosome profiling of exhausted human CD8+ T cells reveals marked repression of 5'TOP mRNAs despite elevated mTOR activity, uncovering a layer of translational control that overrides or bypasses mTOR in T cell exhaustion. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
← The whole pathway · This link as JSON
Thank you. Your answer was counted anonymously.
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.