{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC1-TOPMRNA",
  "claim": "mTORC1 activates 5'TOP mRNA",
  "source": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "target": {
   "name": "5'TOP mRNA",
   "entity": "5top-mrna"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "minutes",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "human cells",
   "Drosophila"
  ],
  "mechanism": "mTORC1 raises translation of the 5'TOP class of mRNAs, which encode ribosomal proteins and translation factors. Ribosome profiling showed the effect is selective rather than uniform: mTORC1 does not turn all translation up equally, it shifts which transcripts get translated.",
  "mechanism_beginner": "When mTORC1 is on, the cell does not simply make more of every protein. It preferentially makes the parts of its own protein-making machinery, from a particular class of messages marked at one end.",
  "context": null,
  "boundary": "The selectivity is from ribosome profiling in cancer cell lines (HSI2012); the lifespan link is Drosophila only (WAN2026); PLEDGER2026 shows the same arm being repressed in chronically activated human CD8+ T cells. No human in vivo measurement of 5'TOP translation under an mTOR inhibitor in this corpus. Which of the 5'TOP transcripts matter for which phenotype is not resolved.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "HSI2012",
    "WAN2026",
    "PLEDGER2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC1-TOPMRNA/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC1-TOPMRNA.json"
 }
}