TFEB links autophagy to lysosomal biogenesis

Autophagy is a cellular catabolic process that relies on the cooperation of autophagosomes and lysosomes. During starvation, the cell expands both compartments to enhance degradation processes. We found that starvation activates a transcriptional program that controls major steps of the autophagic pathway, including autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. The transcription factor EB (TFEB), a master gene for lysosomal biogenesis, coordinated this program by driving expression of autophagy and lysosomal genes.

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Settembre, C., Di Malta, C., Polito, V. A., Garcia Arencibia, M., Vetrini, F., Erdin, S., & Ballabio, A. (2011). TFEB links autophagy to lysosomal biogenesis. Science. https://doi.org/10.1126/science.1204592

@article{SET2011,
  author       = {Settembre, C. and Di Malta, C. and Polito, V. A. and Garcia Arencibia, M. and Vetrini, F. and Erdin, S. and Ballabio, A.},
  title        = {{TFEB links autophagy to lysosomal biogenesis}},
  journal      = {Science},
  year         = {2011},
  doi          = {10.1126/science.1204592},
  note         = {PMID: 21617040},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SET2011) [Data set]. https://mtor-atlas.org/study/SET2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SET2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SET2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SET2011/},
  doi          = {10.5281/zenodo.22059963}
}