ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

Ganley IG, Lam DH, Wang J, Ding X, Chen S, Jiang X · 2009 · The Journal of biological chemistry · Atlas ID GAN2009

What this study shows

The ULK1-ATG13-FIP200 complex transmits mTOR signalling to initiate autophagy.

Abstract

ShowHide

Autophagy is a degradative process that recycles long-lived and faulty cellular components. It is linked to many diseases and is required for normal development. ULK1, a mammalian serine/threonine protein kinase, plays a key role in the initial stages of autophagy, though the exact molecular mechanism is unknown. Here we report identification of a novel protein complex containing ULK1 and two additional protein factors, FIP200 and ATG13, all of which are essential for starvation-induced autophagy.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	The Journal of biological chemistry
Year	2009
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1074/jbc.M900573200 · PMID 19258318 · Free full text (PMC2673298)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/biochemical (ULK1-ATG13-FIP200)
Target	mTOR / ULK1-ATG13-FIP200
Model	Mammalian cells
Effect	The ULK1-ATG13-FIP200 complex mediates mTOR signaling and is essential for autophagy

In the Atlas

Links in the pathway map

Supports mTORC1 inhibits ULK1
Supports ULK1 activates Autophagy

Cite this paper

ShowHide

Ganley, I. G., Lam, D. H., Wang, J., Ding, X., Chen, S., & Jiang, X. (2009). ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. The Journal of biological chemistry. https://doi.org/10.1074/jbc.M900573200

@article{GAN2009,
  author       = {Ganley, I. G. and Lam, D. H. and Wang, J. and Ding, X. and Chen, S. and Jiang, X.},
  title        = {{ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy}},
  journal      = {The Journal of biological chemistry},
  year         = {2009},
  doi          = {10.1074/jbc.M900573200},
  note         = {PMID: 19258318},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GAN2009) [Data set]. https://mtor-atlas.org/study/GAN2009/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAN2009,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAN2009},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAN2009/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?