ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

Autophagy is a degradative process that recycles long-lived and faulty cellular components. It is linked to many diseases and is required for normal development. ULK1, a mammalian serine/threonine protein kinase, plays a key role in the initial stages of autophagy, though the exact molecular mechanism is unknown. Here we report identification of a novel protein complex containing ULK1 and two additional protein factors, FIP200 and ATG13, all of which are essential for starvation-induced autophagy.

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Ganley, I. G., et al. (2009). ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. The Journal of biological chemistry. https://doi.org/10.1074/jbc.M900573200

@article{GAN2009,
  author       = {Ganley, I. G. and Jiang, X. and others},
  title        = {{ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy}},
  journal      = {The Journal of biological chemistry},
  year         = {2009},
  doi          = {10.1074/jbc.M900573200},
  note         = {PMID: 19258318},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GAN2009) [Data set]. https://mtor-atlas.org/study/GAN2009/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAN2009,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAN2009},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAN2009/},
  doi          = {10.5281/zenodo.22059963}
}