Xuejun Jiang
Cell biologist who studies autophagy and programmed cell death, including the ULK1-ATG13-FIP200 complex that links mTOR signalling to autophagy.
Virginia and Daniel K. Ludwig Chair and Lab Head, Cell Biology Program, Memorial Sloan Kettering Cancer Center · PhD, UT Southwestern Medical Center
Xuejun Jiang Lab, Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (New York, New York, USA) ↗ Lab lineage1 direct trainee →
Portrait: Memorial Sloan Kettering Cancer Center
Xuejun Jiang leads a laboratory in the Cell Biology Program of the Sloan Kettering Institute. His group studies programmed cell death, such as apoptosis and ferroptosis, and autophagy, the process by which cells recycle their own parts, and how both matter in cancer.
In the 2009 paper in this Atlas, he was the senior author with first author Ian Ganley. The team found a protein complex made of ULK1, ATG13 and FIP200, and showed that all three are needed for autophagy triggered by starvation. ATG13 and ULK1 are phosphorylated through the mTOR pathway depending on nutrient supply.
This made the complex a switchboard: when nutrients are plentiful, mTOR keeps autophagy in check, and when they run low, the complex is released to start building autophagosomes.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2009 | M | ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy GAN2009 Senior author. The ULK1-ATG13-FIP200 complex is essential for starvation-induced autophagy, and ULK1 and ATG13 are phosphorylated by the mTOR pathway in a nutrient-dependent way. |
Co-authors in the Atlas
People with a profile here who share at least one study with Xuejun Jiang.
- Ian G. Ganley Showed, in one of three 2009 studies (alongside the Mizushima and Kim laboratories), that the ULK1–ATG13–FIP200 complex relays mTOR signalling to start autophagy, and studies how cells select damaged mitochondria for destruction
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