DNA methylation age analysis of rapamycin in common marmosets.

Horvath S, Zoller JA, Haghani A, Lu AT, Raj K, Jasinska AJ, Mattison JA, Salmon AB · 2021 · GeroScience · Atlas ID HOR2021

What this study shows

The authors built two epigenetic clocks for common marmoset blood from DNA methylation data; the human-marmoset clock for relative age correlated moderately well with age in vervet monkeys and rhesus macaques. In a separate marmoset cohort they tested whether rapamycin would change epigenetic age. The clocks did not detect a significant effect of rapamycin on the epigenetic age of marmoset blood. Boundary: a null result on one biomarker (DNA methylation age in blood). It does not show that rapamycin has no effect on aging in marmosets, only that these clocks did not register one; the abstract gives no dose, duration or group size.

Abstract

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Human DNA methylation data have previously been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Subsequent studies demonstrate that similar epigenetic clocks can also be developed for mice and many other mammals. Here, we describe epigenetic clocks for common marmosets (Callithrix jacchus) based on novel DNA methylation data generated from highly conserved mammalian CpGs that were profiled using a custom Infinium array (HorvathMammalMethylChip40). From these, we developed and present here two epigenetic clocks for marmosets that are applicable to whole blood samples.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal study reporting a negative or null result (model: Common marmoset (Callithrix jacchus) whole blood, DNA methylation array, rapamycin cohort; vervet and rhesus macaque for clock comparison); a well-designed null result is still evidence, and the code names the system studied, not the importance.
Study type	4 - Animal Study
Model system	Common marmoset (Callithrix jacchus) whole blood, DNA methylation array, rapamycin cohort; vervet and rhesus macaque for clock comparison
Journal	GeroScience
Year	2021
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s11357-021-00438-7 · PMID 34482522 · Free full text (PMC8599537)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Rapamycin (regimen not stated in abstract)
Target	DNA methylation age (epigenetic clock) in blood
Model	Common marmoset (Callithrix jacchus)
Effect	No significant effect of rapamycin on marmoset blood epigenetic age

In the Atlas

Cite this paper

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Horvath, S., Zoller, J. A., Haghani, A., Lu, A. T., Raj, K., Jasinska, A. J., Mattison, J. A., & Salmon, A. B. (2021). DNA methylation age analysis of rapamycin in common marmosets. GeroScience. https://doi.org/10.1007/s11357-021-00438-7

@article{HOR2021,
  author       = {Horvath, S. and Zoller, J. A. and Haghani, A. and Lu, A. T. and Raj, K. and Jasinska, A. J. and Mattison, J. A. and Salmon, A. B.},
  title        = {{DNA methylation age analysis of rapamycin in common marmosets}},
  journal      = {GeroScience},
  year         = {2021},
  doi          = {10.1007/s11357-021-00438-7},
  note         = {PMID: 34482522},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HOR2021) [Data set]. https://mtor-atlas.org/study/HOR2021/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HOR2021,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HOR2021},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HOR2021/},
  doi          = {10.5281/zenodo.22059963}
}

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