Oliver's mTOR Atlas Evidence Platform
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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD · 2012 · Molecular cell · Atlas ID DIB2012

What this study shows

TBC1D7 is the third core subunit of the TSC1-TSC2 complex regulating Rheb/mTORC1.

Abstract

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The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its GTPase-activating protein (GAP) activity toward Rheb, this complex inhibits the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a key promoter of cell growth. Here, we identify and biochemically characterize TBC1D7 as a stably associated and ubiquitous third core subunit of the TSC1-TSC2 complex.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalMolecular cell
Year2012
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.1016/j.molcel.2012.06.009 · PMID 22795129 · Free full text (PMC3693578)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

InterventionBiochemical/genetic (TBC1D7)
TargetTSC1-TSC2-TBC1D7 / Rheb / mTORC1
ModelMammalian cells
EffectTBC1D7 is a third subunit of the TSC1-TSC2 complex that regulates Rheb and mTORC1

In the Atlas

Related topics

TBC1D7

Links in the pathway map

Learn the biology

Want to understand the biology behind this study? → The TSC Complex — Where the Inputs Meet

Cite this paper

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Dibble, C. C., Elis, W., Menon, S., Qin, W., Klekota, J., Asara, J. M., Finan, P. M., Kwiatkowski, D. J., Murphy, L. O., & Manning, B. D. (2012). TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Molecular cell. https://doi.org/10.1016/j.molcel.2012.06.009

@article{DIB2012,
  author       = {Dibble, C. C. and Elis, W. and Menon, S. and Qin, W. and Klekota, J. and Asara, J. M. and Finan, P. M. and Kwiatkowski, D. J. and Murphy, L. O. and Manning, B. D.},
  title        = {{TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1}},
  journal      = {Molecular cell},
  year         = {2012},
  doi          = {10.1016/j.molcel.2012.06.009},
  note         = {PMID: 22795129},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record DIB2012) [Data set]. https://mtor-atlas.org/study/DIB2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DIB2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DIB2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DIB2012/},
  doi          = {10.5281/zenodo.22059963}
}
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