Oliver's mTOR Atlas Evidence Platform
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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

Dibble CC, Manning BD et al. · 2012 · Molecular cell · Atlas ID DIB2012

What this study shows

TBC1D7 is the third core subunit of the TSC1-TSC2 complex regulating Rheb/mTORC1.

Abstract

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The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its GTPase-activating protein (GAP) activity toward Rheb, this complex inhibits the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a key promoter of cell growth. Here, we identify and biochemically characterize TBC1D7 as a stably associated and ubiquitous third core subunit of the TSC1-TSC2 complex.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalMolecular cell
Year2012
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1016/j.molcel.2012.06.009 · PMID 22795129 · Free full text (PMC3693578)

Extracted findings

InterventionBiochemical/genetic (TBC1D7)
TargetTSC1-TSC2-TBC1D7 / Rheb / mTORC1
ModelMammalian cells
EffectTBC1D7 is a third subunit of the TSC1-TSC2 complex that regulates Rheb and mTORC1

In the Atlas

Related topics

TBC1D7

Learn the biology

Want to understand the biology behind this study? → The TSC Complex — Where the Inputs Meet

Cite this paper

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Dibble, C. C., et al. (2012). TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Molecular cell. https://doi.org/10.1016/j.molcel.2012.06.009

@article{DIB2012,
  author       = {Dibble, C. C. and Manning, B. D. and others},
  title        = {{TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1}},
  journal      = {Molecular cell},
  year         = {2012},
  doi          = {10.1016/j.molcel.2012.06.009},
  note         = {PMID: 22795129},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record DIB2012) [Data set]. https://mtor-atlas.org/study/DIB2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DIB2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DIB2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DIB2012/},
  doi          = {10.5281/zenodo.22059963}
}