Caloric restriction

Intervention · 4 studies in the Atlas

Reduced caloric intake without malnutrition; associated with lifespan extension across species.

Evidence at a glance

Tier	What it means	Studies
B	Direct human evidence	1
C	Animal in vivo	2
D	Mechanistic / in vitro / review	1

Studies

Study	Year	Tier	Finding
ROM2016	2016	B	Two years of sustained 25% caloric restriction in healthy non-obese adults was safe overall, though it lowered bone density more than controls.
MAT2017	2017	C	Direct comparison of two long-term primate CR studies (NIA, Wisconsin) confirms health benefits; survival effect depended on study design.
ZID2009	2009	C	Connected the dots between diet, mTOR, and lifespan. Dietary restriction lowers mTOR activity, which frees up 4E-BP - and here 4E-BP was shown to be REQUIRED for the lifespan boost, working by selecti
FON2010	2010	D	The landmark synthesis showing that eating less (dietary restriction) and dialing down nutrient-sensing pathways - mTOR and growth hormone/IGF-1 - extend healthy lifespan by the SAME conserved mechani

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