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Rheb promotes cell growth as a component of the insulin/TOR signalling network

Saucedo LJ, Edgar BA et al. · 2003 · Nature cell biology · Atlas ID SAU2003

What this study shows

Rheb promotes cell growth as a component of the insulin/TOR network in Drosophila.

Abstract

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Insulin signalling is a potent stimulator of cell growth and has been proposed to function, at least in part, through the conserved protein kinase TOR (target of rapamycin). Recent studies suggest that the tuberous sclerosis complex Tsc1-Tsc2 may couple insulin signalling to Tor activity. However, the regulatory mechanism involved remains unclear, and additional components are most probably involved. In a screen for novel regulators of growth, we identified Rheb (Ras homologue enriched in brain), a member of the Ras superfamily of GTP-binding proteins.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Drosophila) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemDrosophila
JournalNature cell biology
Year2003
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1038/ncb996 · PMID 12766776

Extracted findings

InterventionGenetic (Rheb screen)
TargetRheb / TOR
ModelDrosophila
EffectRheb promotes cell growth as a component of the insulin/TOR signalling network

In the Atlas

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Cite this paper

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Saucedo, L. J., et al. (2003). Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nature cell biology. https://doi.org/10.1038/ncb996

@article{SAU2003,
  author       = {Saucedo, L. J. and Edgar, B. A. and others},
  title        = {{Rheb promotes cell growth as a component of the insulin/TOR signalling network}},
  journal      = {Nature cell biology},
  year         = {2003},
  doi          = {10.1038/ncb996},
  note         = {PMID: 12766776},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record SAU2003) [Data set]. https://mtor-atlas.org/study/SAU2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAU2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAU2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAU2003/},
  doi          = {10.5281/zenodo.22059963}
}