Bruce A. Edgar
A Drosophila geneticist who studies how cells and tissues control their growth, including the role of Rheb in the insulin/TOR network.
Professor, Oncological Sciences, University of Utah · Huntsman Cancer Institute (since 2016) · ZMBH & DKFZ Heidelberg (2009–2016) · Fred Hutchinson Cancer Research Center (from 1993)
Edgar Lab, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah (Salt Lake City, Utah, USA) ↗ Lab lineagetrained under Patrick H. O'Farrell →
Portrait: University of Utah
Bruce Edgar studies how cells and whole tissues decide how big to grow, mostly using the fruit fly Drosophila. He did postdoctoral work at UCSF with Pat O'Farrell and at Oxford with Paul Nurse, started his own lab at the Fred Hutchinson Cancer Research Center in Seattle in 1993, and worked in Heidelberg, Germany, from 2009 to 2016. Since 2016 his lab has been at the Huntsman Cancer Institute at the University of Utah.
In the 2003 study in this Atlas, his group screened for new regulators of growth and found Rheb, a small GTP-binding protein. Flies with extra Rheb grew larger cells and sped up the cell cycle, while flies lacking Rheb stopped growing as young larvae. Genetic and biochemical tests placed Rheb in the insulin pathway, below the Tsc1-Tsc2 complex and above TOR.
Rheb is now a textbook part of the mTORC1 pathway, the switch that links growth signals to the TOR kinase. The same lab went on to study growth and stem cells in the fly gut.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2003 | M | Rheb promotes cell growth as a component of the insulin/TOR signalling network SAU2003 Senior author of the Drosophila study that identified Rheb as a growth regulator acting downstream of Tsc1-Tsc2 and upstream of TOR, and showed it can drive cell growth in starved animals. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Bruce A. Edgar.
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- Leslie J. Saucedo Fruit-fly cell biologist and teacher who, as a postdoc in Bruce Edgar's lab, showed that the small GTPase Rheb drives cell growth in the insulin/TOR pathway
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