SZT2 dictates GATOR control of mTORC1 signalling

Peng M, Yin N, Li MO · 2017 · Nature · Atlas ID PEN2017

What this study shows

SZT2 organizes GATOR1/GATOR2 to dictate amino-acid control of mTORC1.

Abstract

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Mechanistic target of rapamycin complex 1 (TORC1) integrates nutrient signals to control cell growth and organismal homeostasis across eukaryotes. The evolutionarily conserved GATOR complex regulates mTORC1 signalling through Rag GTPases, and GATOR1 displays GTPase activating protein (GAP) activity for RAGA and RAGB (RAGA/B) and GATOR2 has been proposed to be an inhibitor of GATOR1. Furthermore, the metazoan-specific SESN proteins function as guanine nucleotide dissociation inhibitors (GDIs) for RAGA/B, and interact with GATOR2 with unknown effects.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Nature
Year	2017
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nature21378 · PMID 28199315 · Free full text (PMC5570594)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/biochemical (SZT2 / KICSTOR)
Target	SZT2 / GATOR / Rag / mTORC1
Model	Mammalian cells
Effect	SZT2 dictates GATOR control of mTORC1 signalling

In the Atlas

Links in the pathway map

Supports KICSTOR required-for GATOR1

Cite this paper

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Peng, M., Yin, N., & Li, M. O. (2017). SZT2 dictates GATOR control of mTORC1 signalling. Nature. https://doi.org/10.1038/nature21378

@article{PEN2017,
  author       = {Peng, M. and Yin, N. and Li, M. O.},
  title        = {{SZT2 dictates GATOR control of mTORC1 signalling}},
  journal      = {Nature},
  year         = {2017},
  doi          = {10.1038/nature21378},
  note         = {PMID: 28199315},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PEN2017) [Data set]. https://mtor-atlas.org/study/PEN2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PEN2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PEN2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PEN2017/},
  doi          = {10.5281/zenodo.22059963}
}

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