KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, …, Sabatini DM · 2017 · Nature · Atlas ID WOL2017

What this study shows

KICSTOR tethers GATOR1 to the lysosome, required for nutrient control of mTORC1.

Abstract

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The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are a key input to this system, and act through the Rag GTPases to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. Multiple protein complexes regulate the Rag GTPases in response to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positive regulator of unknown molecular function.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Nature
Year	2017
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nature21423 · PMID 28199306 · Free full text (PMC5360989)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (KICSTOR)
Target	KICSTOR / GATOR1 / Rag / mTORC1
Model	Mammalian cells
Effect	KICSTOR recruits GATOR1 to the lysosome and is required for nutrients to regulate mTORC1

In the Atlas

Links in the pathway map

Supports KICSTOR required-for GATOR1

Cite this paper

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Wolfson, R. L., Chantranupong, L., Wyant, G. A., Gu, X., Orozco, J. M., Shen, K., Condon, K. J., Petri, S., Kedir, J., Scaria, S. M., Abu-Remaileh, M., Frankel, W. N., & Sabatini, D. M. (2017). KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. https://doi.org/10.1038/nature21423

@article{WOL2017,
  author       = {Wolfson, R. L. and Chantranupong, L. and Wyant, G. A. and Gu, X. and Orozco, J. M. and Shen, K. and Condon, K. J. and Petri, S. and Kedir, J. and Scaria, S. M. and Abu-Remaileh, M. and Frankel, W. N. and Sabatini, D. M.},
  title        = {{KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1}},
  journal      = {Nature},
  year         = {2017},
  doi          = {10.1038/nature21423},
  note         = {PMID: 28199306},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WOL2017) [Data set]. https://mtor-atlas.org/study/WOL2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WOL2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WOL2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WOL2017/},
  doi          = {10.5281/zenodo.22059963}
}

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