KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are a key input to this system, and act through the Rag GTPases to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. Multiple protein complexes regulate the Rag GTPases in response to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positive regulator of unknown molecular function.

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Wolfson, R. L., et al. (2017). KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. https://doi.org/10.1038/nature21423

@article{WOL2017,
  author       = {Wolfson, R. L. and Sabatini, D. M. and others},
  title        = {{KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1}},
  journal      = {Nature},
  year         = {2017},
  doi          = {10.1038/nature21423},
  note         = {PMID: 28199306},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WOL2017) [Data set]. https://mtor-atlas.org/study/WOL2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WOL2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WOL2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WOL2017/},
  doi          = {10.5281/zenodo.22059963}
}