Pathway link KICSTOR-GATOR1

KICSTOR – GATOR1

KICSTOR required-for GATOR1.

KICSTOR works like a docking clamp that holds GATOR1 in place on the lysosome; without it, GATOR1 can't reach its target.

KICSTOR is the dock that holds GATOR1 on the lysosomal surface. Without it, GATOR1 cannot reach its target and nutrient control of mTORC1 is lost.

The conditions it holds under

Mammalian cell genetics (WOL2017, PEN2017). The dependency is shown in cultured cells; whole-animal and human relevance are not tested in the cited work.

Time it takes

always on

Step

direct (one molecule acts on the other)

Measured in

human cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

settled in the literature

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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