Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex-comprising DEPDC5, NPRL2 and NPRL3-regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation. GATOR1 components have no sequence homology to other proteins, so the function of GATOR1 at the molecular level is currently unknown. Here we used cryo-electron microscopy to solve structures of GATOR1 and GATOR1-Rag GTPases complexes.

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Shen, K., et al. (2018). Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. https://doi.org/10.1038/nature26158

@article{SHE2018,
  author       = {Shen, K. and Sabatini, D. M. and others},
  title        = {{Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes}},
  journal      = {Nature},
  year         = {2018},
  doi          = {10.1038/nature26158},
  note         = {PMID: 29590090},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SHE2018) [Data set]. https://mtor-atlas.org/study/SHE2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SHE2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SHE2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SHE2018/},
  doi          = {10.5281/zenodo.22059963}
}