Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1

The Rag family of guanosine triphosphatases (GTPases) regulates eukaryotic cell growth in response to amino acids by activating the target of rapamycin complex 1 (TORC1). In humans, this pathway is often deregulated in cancer. In yeast, amino acids promote binding of GTP (guanosine 5'-triphosphate) to the Rag family GTPase Gtr1, which, in combination with a GDP (guanosine diphosphate)-bound Gtr2, forms the active, TORC1-stimulating GTPase heterodimer. We identified Iml1, which functioned in a complex with Npr2 and Npr3, as a GAP (GTPase-activating protein) for Gtr1.

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Panchaud, N., et al. (2013). Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Science signaling. https://doi.org/10.1126/scisignal.2004112

@article{PAN2013,
  author       = {Panchaud, N. and De Virgilio, C. and others},
  title        = {{Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1}},
  journal      = {Science signaling},
  year         = {2013},
  doi          = {10.1126/scisignal.2004112},
  note         = {PMID: 23716719},
}

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Barton, O. (2026). Oliver's mTOR Atlas (record PAN2013) [Data set]. https://mtor-atlas.org/study/PAN2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PAN2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PAN2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PAN2013/},
  doi          = {10.5281/zenodo.22059963}
}