Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1

Panchaud N, Péli-Gulli MP, De Virgilio C · 2013 · Science signaling · Atlas ID PAN2013

What this study shows

The SEACIT complex is a GAP for the Rag/Gtr GTPases mediating amino-acid inhibition of TORC1.

Abstract

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The Rag family of guanosine triphosphatases (GTPases) regulates eukaryotic cell growth in response to amino acids by activating the target of rapamycin complex 1 (TORC1). In humans, this pathway is often deregulated in cancer. In yeast, amino acids promote binding of GTP (guanosine 5'-triphosphate) to the Rag family GTPase Gtr1, which, in combination with a GDP (guanosine diphosphate)-bound Gtr2, forms the active, TORC1-stimulating GTPase heterodimer. We identified Iml1, which functioned in a complex with Npr2 and Npr3, as a GAP (GTPase-activating protein) for Gtr1.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Yeast) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Yeast
Journal	Science signaling
Year	2013
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1126/scisignal.2004112 · PMID 23716719

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (SEACIT/GAP for Gtr1)
Target	TORC1 / Gtr1 (Rag) / SEACIT
Model	Yeast
Effect	Amino-acid deprivation inhibits TORC1 through a GAP complex (SEACIT) for the Rag-family GTPase Gtr1

In the Atlas

Cite this paper

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Panchaud, N., Péli-Gulli, M. P., & De Virgilio, C. (2013). Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Science signaling. https://doi.org/10.1126/scisignal.2004112

@article{PAN2013,
  author       = {Panchaud, N. and Péli-Gulli, M. P. and De Virgilio, C.},
  title        = {{Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1}},
  journal      = {Science signaling},
  year         = {2013},
  doi          = {10.1126/scisignal.2004112},
  note         = {PMID: 23716719},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PAN2013) [Data set]. https://mtor-atlas.org/study/PAN2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PAN2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PAN2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PAN2013/},
  doi          = {10.5281/zenodo.22059963}
}

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