SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation

Hu K, Feske S et al. · 2026 · Nat Commun · Atlas ID HU2026B

What this study shows

SLC4A7/NBCn1, a Na/HCO3 cotransporter, maintains intracellular pH needed for mTORC1 activity during B-cell differentiation into antibody-secreting cells; its loss causes intracellular acidification, lysosomal alkalinization, impaired mTORC1 function, and blunted antibody responses in vivo.

Abstract

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Antibody-producing plasmablasts (PB) and plasma cells (PC) are critical for humoral immunity, autoimmunity and vaccine responses. Despite the importance of environmental stressors in regulating humoral immune responses, the influence of pH on PB and PC differentiation remains elusive. Here, we identify SLC4A7/NBCn1, a Na/HCO3- cotransporter, as a selective regulator of PB differentiation in vitro. SLC4A7 deletion also impairs the formation of antibody secreting cells (ASCs) and antibody responses in mice in vivo following immunization and influenza A virus infection.

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At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse (SLC4A7 conditional knockout, in vivo immunization/influenza infection); primary B cells in vitro); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse (SLC4A7 conditional knockout, in vivo immunization/influenza infection); primary B cells in vitro
Journal	Nat Commun
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/s41467-026-77588-9 · PMID 42823451 · Free full text (PMC13631254)

In the Atlas

Cite this paper

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Hu, K., et al. (2026). SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation. Nat Commun. https://doi.org/10.1038/s41467-026-77588-9

@article{HU2026B,
  author       = {Hu, K. and Feske, S. and others},
  title        = {{SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation}},
  journal      = {Nat Commun},
  year         = {2026},
  doi          = {10.1038/s41467-026-77588-9},
  note         = {PMID: 42823451},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HU2026B) [Data set]. https://mtor-atlas.org/study/HU2026B/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HU2026B,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HU2026B},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HU2026B/},
  doi          = {10.5281/zenodo.22059963}
}

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