Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

Birt-Hogg-Dube syndrome, a human disease characterized by fibrofolliculomas (hair follicle tumors) as well as a strong predisposition toward the development of pneumothorax, pulmonary cysts, and renal carcinoma, arises from loss-of-function mutations in the folliculin (FLCN) gene. In this study, we show that FLCN regulates lysosome function by promoting the mTORC1-dependent phosphorylation and cytoplasmic sequestration of transcription factor EB (TFEB). Our results indicate that FLCN is specifically required for the amino acid-stimulated recruitment of mTORC1 to lysosomes by Rag GTPases.

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Petit, C. S., et al. (2013). Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. The Journal of cell biology. https://doi.org/10.1083/jcb.201307084

@article{PET2013,
  author       = {Petit, C. S. and Ferguson, S. M. and others},
  title        = {{Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases}},
  journal      = {The Journal of cell biology},
  year         = {2013},
  doi          = {10.1083/jcb.201307084},
  note         = {PMID: 24081491},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PET2013) [Data set]. https://mtor-atlas.org/study/PET2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PET2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PET2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PET2013/},
  doi          = {10.5281/zenodo.22059963}
}