Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

Petit CS, Roczniak-Ferguson A, Ferguson SM · 2013 · The Journal of cell biology · Atlas ID PET2013

What this study shows

Folliculin (FLCN) gathers on lysosomes when amino acids are removed and binds RagA directly; FLCN is required for amino acids to recruit mTORC1 to lysosomes via the Rag GTPases.

Abstract

ShowHide

Birt-Hogg-Dube syndrome, a human disease characterized by fibrofolliculomas (hair follicle tumors) as well as a strong predisposition toward the development of pneumothorax, pulmonary cysts, and renal carcinoma, arises from loss-of-function mutations in the folliculin (FLCN) gene. In this study, we show that FLCN regulates lysosome function by promoting the mTORC1-dependent phosphorylation and cytoplasmic sequestration of transcription factor EB (TFEB). Our results indicate that FLCN is specifically required for the amino acid-stimulated recruitment of mTORC1 to lysosomes by Rag GTPases.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	The Journal of cell biology
Year	2013
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1083/jcb.201307084 · PMID 24081491 · Free full text (PMC3787382)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/biochemical (FLCN)
Target	FLCN / Rag GTPases / mTORC1
Model	Mammalian cells
Effect	FLCN is recruited to lysosomes on amino-acid depletion, binds RagA, and is required for amino-acid-stimulated recruitment of mTORC1 to lysosomes by the Rag GTPases

In the Atlas

Cite this paper

ShowHide

Petit, C. S., Roczniak-Ferguson, A., & Ferguson, S. M. (2013). Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. The Journal of cell biology. https://doi.org/10.1083/jcb.201307084

@article{PET2013,
  author       = {Petit, C. S. and Roczniak-Ferguson, A. and Ferguson, S. M.},
  title        = {{Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases}},
  journal      = {The Journal of cell biology},
  year         = {2013},
  doi          = {10.1083/jcb.201307084},
  note         = {PMID: 24081491},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PET2013) [Data set]. https://mtor-atlas.org/study/PET2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PET2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PET2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PET2013/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?