The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1

The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting the translocation of mTORC1 to the lysosomal surface, its site of activation. The Rags are unusual GTPases in that they function as obligate heterodimers, which consist of RagA or B bound to RagC or D. While the loading of RagA/B with GTP initiates amino acid signaling to mTORC1, the role of RagC/D is unknown.

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Tsun, Z. Y., et al. (2013). The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Molecular cell. https://doi.org/10.1016/j.molcel.2013.09.016

@article{TSU2013,
  author       = {Tsun, Z. Y. and Sabatini, D. M. and others},
  title        = {{The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1}},
  journal      = {Molecular cell},
  year         = {2013},
  doi          = {10.1016/j.molcel.2013.09.016},
  note         = {PMID: 24095279},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record TSU2013) [Data set]. https://mtor-atlas.org/study/TSU2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_TSU2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record TSU2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/TSU2013/},
  doi          = {10.5281/zenodo.22059963}
}