The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1

Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM · 2013 · Molecular cell · Atlas ID TSU2013

What this study shows

FLCN-FNIP is a GAP for RagC/D; GDP-bound RagC/D is required for the Rag heterodimer to bind mTORC1, promoting its lysosomal recruitment and activation by amino acids.

Abstract

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The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting the translocation of mTORC1 to the lysosomal surface, its site of activation. The Rags are unusual GTPases in that they function as obligate heterodimers, which consist of RagA or B bound to RagC or D. While the loading of RagA/B with GTP initiates amino acid signaling to mTORC1, the role of RagC/D is unknown.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Molecular cell
Year	2013
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.molcel.2013.09.016 · PMID 24095279 · Free full text (PMC3867817)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (FLCN)
Target	FLCN / RagC-RagD / mTORC1
Model	Mammalian cells
Effect	The folliculin tumor suppressor is a GAP for RagC/D that signals amino-acid levels to mTORC1

In the Atlas

Cite this paper

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Tsun, Z. Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013). The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Molecular cell. https://doi.org/10.1016/j.molcel.2013.09.016

@article{TSU2013,
  author       = {Tsun, Z. Y. and Bar-Peled, L. and Chantranupong, L. and Zoncu, R. and Wang, T. and Kim, C. and Spooner, E. and Sabatini, D. M.},
  title        = {{The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1}},
  journal      = {Molecular cell},
  year         = {2013},
  doi          = {10.1016/j.molcel.2013.09.016},
  note         = {PMID: 24095279},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record TSU2013) [Data set]. https://mtor-atlas.org/study/TSU2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_TSU2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record TSU2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/TSU2013/},
  doi          = {10.5281/zenodo.22059963}
}

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