Tim Wang
Helped show that 4E-BP proteins are mTORC1's master translation-control switch and that CASTOR1 is its arginine sensor
Graduate & postdoctoral research, Sabatini Lab · later traced to Janelia Research Campus (HHMI), computational/quantitative scientist · most recent record (2024) co-affiliated with Allen Institute for Neural Dynamics — current status unconfirmed
Co-author (THO2012): ribosome profiling with Torin1 showed mTORC1 controls translation of TOP-motif mRNAs largely through 4E-BPs. Co-author (CHA2016): CASTOR1 identified as the direct arginine sensor upstream of mTORC1.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | A unifying model for mTORC1-mediated regulation of mRNA translation THO2012 Co-authored the ribosome-profiling study showing 4E-BPs are mTORC1's master translational effectors. |
| 2016 | M | The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway CHA2016 Co-authored the CASTOR1 arginine-sensor discovery. |