Elizabeth D. Yuan

Second author on the study showing that S6K1 phosphorylates BMAL1 to link mTOR signalling with circadian protein synthesis, and co-author on the follow-up in tuberous sclerosis models.

Research staff, Sahin Lab, Boston Children's Hospital (per 2015–2017 paper affiliations) · earlier co-author from the Sabatini lab, Whitehead Institute (2015) · later listed at University of Massachusetts Medical School (2017, per PubMed)

Yuan was second author on the paper showing that the mTOR target S6K1 phosphorylates BMAL1 and that this lets BMAL1 drive protein synthesis on a daily rhythm (LIP2015). She was also a co-author on the follow-up showing that mTOR overactivity in tuberous sclerosis mouse models raises BMAL1 and disturbs the clock (LIP2017).

PubMed also lists an Elizabeth D. Yuan at the Whitehead Institute as a co-author on the 2015 Sabatini-lab paper on the arginine transporter SLC38A9, and at the University of Massachusetts Medical School on a 2017 medical-education paper. Her current position could not be verified.

Milestones in the Atlas

A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.

Co-authors in the Atlas

People with a profile here who share at least one study with Elizabeth D. Yuan.

• Ashwin Nathan 2 shared studies Co-author on both Boston Children's Hospital studies linking mTOR signalling to the circadian clock protein BMAL1.
• Fred C. Davis 2 shared studies Circadian biologist from Northeastern University who brought expertise on the brain's master clock to two studies linking mTOR and the clock protein BMAL1.
• Jonathan O. Lipton 2 shared studies First author of the two studies that tie mTOR signalling to the circadian clock protein BMAL1: S6K1 phosphorylates BMAL1 to drive translation, and constant mTOR activity in tuberous sclerosis disturbs the clock.
• Lara M. Boyle 2 shared studies Research assistant at Boston Children's Hospital who co-authored both studies linking mTOR to the clock protein BMAL1, including the tuberous sclerosis study where she was second author.
• Mustafa Sahin 2 shared studies Senior author of the studies showing that mTOR signalling reaches the circadian clock through BMAL1, and a physician-scientist focused on tuberous sclerosis, the classic disease of overactive mTOR.
• John M. Asara Mass-spectrometry specialist whose core facility supplied metabolomics and proteomics for several mTOR studies, including measurements of purine, pyrimidine and SAM metabolism downstream of mTORC1.

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