Ashwin Nathan
Co-author on both Boston Children's Hospital studies linking mTOR signalling to the circadian clock protein BMAL1.
Listed at the F.M. Kirby Neurobiology Center, Boston Children's Hospital, on the 2015 and 2017 papers; current position not verified
Nathan was a co-author on the study showing that S6K1, downstream of mTORC1, phosphorylates BMAL1 so that it can promote protein synthesis (LIP2015), and on the follow-up showing that mTOR overactivity in tuberous sclerosis mouse models deregulates BMAL1 and the clock (LIP2017).
Both papers list him at the Department of Neurology, Boston Children's Hospital. His later career could not be confirmed from an open source.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2015 | A | The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation LIP2015 Co-author on the discovery that S6K1 phosphorylates BMAL1 to link mTOR and circadian translation. |
| 2017 | A | Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy LIP2017 Co-author on the study of BMAL1 deregulation and circadian defects in tuberous sclerosis models. |
Co-authors in the Atlas
People with a profile here who share at least one study with Ashwin Nathan.
- Elizabeth D. Yuan 2 shared studies Second author on the study showing that S6K1 phosphorylates BMAL1 to link mTOR signalling with circadian protein synthesis, and co-author on the follow-up in tuberous sclerosis models.
- Fred C. Davis 2 shared studies Circadian biologist from Northeastern University who brought expertise on the brain's master clock to two studies linking mTOR and the clock protein BMAL1.
- Jonathan O. Lipton 2 shared studies First author of the two studies that tie mTOR signalling to the circadian clock protein BMAL1: S6K1 phosphorylates BMAL1 to drive translation, and constant mTOR activity in tuberous sclerosis disturbs the clock.
- Lara M. Boyle 2 shared studies Research assistant at Boston Children's Hospital who co-authored both studies linking mTOR to the clock protein BMAL1, including the tuberous sclerosis study where she was second author.
- Mustafa Sahin 2 shared studies Senior author of the studies showing that mTOR signalling reaches the circadian clock through BMAL1, and a physician-scientist focused on tuberous sclerosis, the classic disease of overactive mTOR.
- John M. Asara Mass-spectrometry specialist whose core facility supplied metabolomics and proteomics for several mTOR studies, including measurements of purine, pyrimidine and SAM metabolism downstream of mTORC1.
Every researcher with a profile →
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