Lara M. Boyle
Research assistant at Boston Children's Hospital who co-authored both studies linking mTOR to the clock protein BMAL1, including the tuberous sclerosis study where she was second author.
Psychiatry resident (research track, class of 2027), University of Pennsylvania · MD/PhD, Columbia University Vagelos College of Physicians and Surgeons · research assistant, Lipton/Sahin labs, Boston Children's Hospital · undergraduate, Yale University
Portrait: Penn Psychiatry Residency, University of Pennsylvania
After college Boyle worked at Boston Children's Hospital on circadian biology in tuberous sclerosis models. She was a co-author on the paper showing that S6K1 phosphorylates BMAL1 (LIP2015) and second author on the study showing that mTOR overactivity raises BMAL1 and disturbs circadian rhythms in these mice (LIP2017).
She studied at Yale, where she worked on chronic stress and fear learning, then completed an MD/PhD at Columbia University with a thesis on social recognition memory in mice. She is now a research-track psychiatry resident at the University of Pennsylvania, where she plans to study how stress and anxiety change neural activity and rhythms during sleep.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2015 | A | The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation LIP2015 Co-author on the discovery that S6K1 phosphorylates BMAL1 to link mTOR and circadian translation. |
| 2017 | A | Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy LIP2017 Second author: circadian abnormalities and BMAL1 deregulation in tuberous sclerosis mouse models. |
Co-authors in the Atlas
People with a profile here who share at least one study with Lara M. Boyle.
- Ashwin Nathan 2 shared studies Co-author on both Boston Children's Hospital studies linking mTOR signalling to the circadian clock protein BMAL1.
- Elizabeth D. Yuan 2 shared studies Second author on the study showing that S6K1 phosphorylates BMAL1 to link mTOR signalling with circadian protein synthesis, and co-author on the follow-up in tuberous sclerosis models.
- Fred C. Davis 2 shared studies Circadian biologist from Northeastern University who brought expertise on the brain's master clock to two studies linking mTOR and the clock protein BMAL1.
- Jonathan O. Lipton 2 shared studies First author of the two studies that tie mTOR signalling to the circadian clock protein BMAL1: S6K1 phosphorylates BMAL1 to drive translation, and constant mTOR activity in tuberous sclerosis disturbs the clock.
- Mustafa Sahin 2 shared studies Senior author of the studies showing that mTOR signalling reaches the circadian clock through BMAL1, and a physician-scientist focused on tuberous sclerosis, the classic disease of overactive mTOR.
- John M. Asara Mass-spectrometry specialist whose core facility supplied metabolomics and proteomics for several mTOR studies, including measurements of purine, pyrimidine and SAM metabolism downstream of mTORC1.
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