Fred C. Davis
Circadian biologist from Northeastern University who brought expertise on the brain's master clock to two studies linking mTOR and the clock protein BMAL1.
Professor of Biology, Northeastern University · PhD in Zoology, University of Texas at Austin · BSc and MSc in Biological Sciences, Stanford University
Davis Lab, Department of Biology, Northeastern University (Boston, Massachusetts, USA) ↗
Portrait: Northeastern University College of Science
Davis was the outside circadian expert on both Boston Children's Hospital studies: the discovery that S6K1 phosphorylates BMAL1 to drive rhythmic protein synthesis (LIP2015), and the finding that mTOR overactivity in tuberous sclerosis mouse models disturbs circadian behaviour through BMAL1 (LIP2017).
He is a Professor of Biology at Northeastern University. His research asks how the suprachiasmatic nucleus, the brain's master clock, coordinates daily rhythms across tissues, especially during development.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2015 | A | The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation LIP2015 Co-author (Northeastern University) contributing circadian expertise to the BMAL1–S6K1 study. |
| 2017 | A | Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy LIP2017 Co-author (Northeastern University) on circadian defects in tuberous sclerosis mouse models. |
Co-authors in the Atlas
People with a profile here who share at least one study with Fred C. Davis.
- Ashwin Nathan 2 shared studies Co-author on both Boston Children's Hospital studies linking mTOR signalling to the circadian clock protein BMAL1.
- Elizabeth D. Yuan 2 shared studies Second author on the study showing that S6K1 phosphorylates BMAL1 to link mTOR signalling with circadian protein synthesis, and co-author on the follow-up in tuberous sclerosis models.
- Jonathan O. Lipton 2 shared studies First author of the two studies that tie mTOR signalling to the circadian clock protein BMAL1: S6K1 phosphorylates BMAL1 to drive translation, and constant mTOR activity in tuberous sclerosis disturbs the clock.
- Lara M. Boyle 2 shared studies Research assistant at Boston Children's Hospital who co-authored both studies linking mTOR to the clock protein BMAL1, including the tuberous sclerosis study where she was second author.
- Mustafa Sahin 2 shared studies Senior author of the studies showing that mTOR signalling reaches the circadian clock through BMAL1, and a physician-scientist focused on tuberous sclerosis, the classic disease of overactive mTOR.
- John M. Asara Mass-spectrometry specialist whose core facility supplied metabolomics and proteomics for several mTOR studies, including measurements of purine, pyrimidine and SAM metabolism downstream of mTORC1.
Every researcher with a profile →
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