Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that exists in two separate complexes, mTORC1 and mTORC2, that function to control cell size and growth in response to growth factors, nutrients, and cellular energy levels. Low molecular weight GTP-binding proteins of the Rheb and Rag families are key regulators of the mTORC1 complex, but regulation of mTORC2 is poorly understood. Here, we report that Rac1, a member of the Rho family of GTPases, is a critical regulator of both mTORC1 and mTORC2 in response to growth-factor stimulation.

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Saci, A., et al. (2011). Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Molecular cell. https://doi.org/10.1016/j.molcel.2011.03.017

@article{SAC2011,
  author       = {Saci, A. and Carpenter, C. L. and others},
  title        = {{Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size}},
  journal      = {Molecular cell},
  year         = {2011},
  doi          = {10.1016/j.molcel.2011.03.017},
  note         = {PMID: 21474067},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SAC2011) [Data set]. https://mtor-atlas.org/study/SAC2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAC2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAC2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAC2011/},
  doi          = {10.5281/zenodo.22059963}
}