In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

Kubota H, Uda S, Matsuzaki F, Yamauchi Y, Kuroda S · 2018 · Cell Systems · Atlas ID KUB2018

What this study shows

The in-vivo follow-up to KUB2012. In rat liver, all temporal patterns of blood insulin were encoded at the insulin receptor, and downstream molecules decoded them selectively through AKT: S6K read the additional (pulse-like) secretion, G6Pase the basal secretion via FoxO1, GSK3-beta all of it. Modelling tied the selectivity to network structure, sensitivity and time constants. Shows that pattern decoding is not only a cell-culture effect.

Abstract

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Cells respond to various extracellular stimuli through a limited number of signaling pathways. One strategy to process such stimuli is to code the information into the temporal patterns of molecules. Although we showed that insulin selectively regulated molecules depending on its temporal patterns using Fao cells, the in vivo mechanism remains unknown. Here, we show how the insulin-AKT pathway processes the information encoded into the temporal patterns of blood insulin.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Rat liver in vivo (hyperinsulinemic-euglycemic clamp with different insulin time patterns) plus mathematical model); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Rat liver in vivo (hyperinsulinemic-euglycemic clamp with different insulin time patterns) plus mathematical model
Journal	Cell Systems
Year	2018
Peer reviewed	Yes
Record last updated	2026-09-23
Source	DOI 10.1016/j.cels.2018.05.013 · PMID 29960883

Extracted findings

Intervention	Insulin delivered in different temporal patterns under clamp
Target	Insulin receptor; AKT; S6K; FoxO1/G6Pase; GSK3-beta
Model	Rat
Effect	S6K selectively decodes additional insulin secretion in vivo

In the Atlas

Cite this paper

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Kubota, H., Uda, S., Matsuzaki, F., Yamauchi, Y., & Kuroda, S. (2018). In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver. Cell Systems. https://doi.org/10.1016/j.cels.2018.05.013

@article{KUB2018,
  author       = {Kubota, H. and Uda, S. and Matsuzaki, F. and Yamauchi, Y. and Kuroda, S.},
  title        = {{In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver}},
  journal      = {Cell Systems},
  year         = {2018},
  doi          = {10.1016/j.cels.2018.05.013},
  note         = {PMID: 29960883},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KUB2018) [Data set]. https://mtor-atlas.org/study/KUB2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KUB2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KUB2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KUB2018/},
  doi          = {10.5281/zenodo.22059963}
}