Maternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria, Management, and Outcomes in a Series of Six Cases

Guibaud L, Bordas-Fournel M, Cabet S, Le Vaillant C, Bruel A, Lefran‡ois T, Megier C, Benachi A, Sohier M, Gallois Y, Somon T, Jouannic J-M · 2026 · Prenatal Diagnosis · Atlas ID GUIB2026

What this study shows

Maternal rapamycin (sirolimus) therapy for extensive fetal lymphatic malformations. Prenatal mTOR inhibition feasible with partial/marked lesion regression in 5/6 newborns; transplacental transfer observed. Observational case series (n=6); confounding by indication not excluded.

At a glance

Evidence type	H Human study Marked H because it is direct evidence from a human clinical trial or human cohort; the code names the kind of study, not its quality -- a small, well-run trial is still H.
Study type	3 - Human Observational
Model system	—
Journal	Prenatal Diagnosis
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1002/pd.70230 · PMID 42607031

Cite this paper

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Guibaud, L., Bordas-Fournel, M., Cabet, S., Le Vaillant, C., Bruel, A., Lefran‡ois, T., Megier, C., Benachi, A., Sohier, M., Gallois, Y., Somon, T., Jouannic J-M, Canaud, G., Guilhem, A., Atallah, A., & Fraissenon, A. (2026). Maternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria, Management, and Outcomes in a Series of Six Cases. Prenatal Diagnosis. https://doi.org/10.1002/pd.70230

@article{GUIB2026,
  author       = {Guibaud, L. and Bordas-Fournel, M. and Cabet, S. and Le Vaillant, C. and Bruel, A. and Lefran‡ois, T. and Megier, C. and Benachi, A. and Sohier, M. and Gallois, Y. and Somon, T. and Jouannic J-M and Canaud, G. and Guilhem, A. and Atallah, A. and Fraissenon, A.},
  title        = {{Maternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria, Management, and Outcomes in a Series of Six Cases}},
  journal      = {Prenatal Diagnosis},
  year         = {2026},
  doi          = {10.1002/pd.70230},
  note         = {PMID: 42607031},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GUIB2026) [Data set]. https://mtor-atlas.org/study/GUIB2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GUIB2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GUIB2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GUIB2026/},
  doi          = {10.5281/zenodo.22059963}
}