Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Rodrik-Outmezguine VS, Shokat KM et al. · 2016 · Nature · Atlas ID ROD2016

What this study shows

RapaLink-1, a third-generation bivalent inhibitor, overcomes mTOR resistance mutations.

Abstract

ShowHide

Precision medicines exert selective pressure on tumour cells that leads to the preferential growth of resistant subpopulations, necessitating the development of next-generation therapies to treat the evolving cancer. The PIK3CA-AKT-mTOR pathway is one of the most commonly activated pathways in human cancers, which has led to the development of small-molecule inhibitors that target various nodes in the pathway.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cancer cells; mouse) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemCancer cells; mouse
JournalNature
Year2016
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1038/nature17963 · PMID 27279227 · Free full text (PMC4902179)

Extracted findings

InterventionNew-generation bivalent mTOR inhibitor (RapaLink-type)
TargetmTOR (resistance mutations)
ModelCancer cells; mouse
EffectA bivalent next-generation inhibitor overcomes mTOR resistance mutations that defeat first- and second-generation drugs

In the Atlas

Related topics

mTOR

Cite this paper

ShowHide 
Rodrik-Outmezguine, V. S., et al. (2016). Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. https://doi.org/10.1038/nature17963

@article{ROD2016,
  author       = {Rodrik-Outmezguine, V. S. and Shokat, K. M. and others},
  title        = {{Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor}},
  journal      = {Nature},
  year         = {2016},
  doi          = {10.1038/nature17963},
  note         = {PMID: 27279227},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record ROD2016) [Data set]. https://mtor-atlas.org/study/ROD2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ROD2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ROD2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ROD2016/},
  doi          = {10.5281/zenodo.22059963}
}