mTOR as a central hub of nutrient signalling and cell growth

Kim J, Guan KL · 2019 · Nature cell biology · Atlas ID KIM2019

What this study shows

Review: mTOR as a central hub of nutrient signalling and cell growth.

Abstract

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The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth regulator connecting cellular metabolism and growth with a wide range of environmental inputs as part of mTOR complex 1 (mTORC1) and mTORC2.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature cell biology
Year	2019
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/s41556-018-0205-1 · PMID 30602761

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTORC1 / mTORC2
Model	Review
Effect	Reviews landmark mTOR discoveries and its role as a central hub of nutrient signalling and cell growth

In the Atlas

Cite this paper

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Kim, J., & Guan, K. L. (2019). mTOR as a central hub of nutrient signalling and cell growth. Nature cell biology. https://doi.org/10.1038/s41556-018-0205-1

@article{KIM2019,
  author       = {Kim, J. and Guan, K. L.},
  title        = {{mTOR as a central hub of nutrient signalling and cell growth}},
  journal      = {Nature cell biology},
  year         = {2019},
  doi          = {10.1038/s41556-018-0205-1},
  note         = {PMID: 30602761},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KIM2019) [Data set]. https://mtor-atlas.org/study/KIM2019/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KIM2019,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KIM2019},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KIM2019/},
  doi          = {10.5281/zenodo.22059963}
}

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