FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling.

Chronic wound healing disorders remain a significant clinical challenge, largely due to the limited effectiveness of conventional therapeutic strategies. Emerging evidence suggests that engineered exosomes represent a promising cell-free therapeutic approach. This study aimed to elucidate the mechanisms by which FGF21-modified adipose-derived mesenchymal stem cell (ADSC) exosomes promote wound healing. ADSCs overexpressing FGF21 were established using genetic engineering, and FGF21-enriched exosomes (Exo@FGF21) were isolated and characterized.

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Chen, K., et al. (2026). FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling. Cellular signalling. https://doi.org/10.1016/j.cellsig.2026.112742

@article{CHEN2026,
  author       = {Chen, K. and Chen, X. and Wen, C. and Chen, W. and Liao, Z. and others},
  title        = {{FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling}},
  journal      = {Cellular signalling},
  year         = {2026},
  doi          = {10.1016/j.cellsig.2026.112742},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CHEN2026) [Data set]. https://mtor-atlas.org/study/CHEN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CHEN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CHEN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CHEN2026/},
  doi          = {10.5281/zenodo.22059963}
}