FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling.

Chen K, Chen X, Wen C, Chen W, Liao Z, Chen Y, Li L · 2026 · Cellular signalling · Atlas ID CHEN2026

What this study shows

FGF21-enriched exosomes from engineered ADSCs promote chronic wound healing by activating fibroblast glycolysis, with AMPK activated and mTOR signaling suppressed, improving proliferation, migration, and tissue repair in a mouse model.

Abstract

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Chronic wound healing disorders remain a significant clinical challenge, largely due to the limited effectiveness of conventional therapeutic strategies. Emerging evidence suggests that engineered exosomes represent a promising cell-free therapeutic approach. This study aimed to elucidate the mechanisms by which FGF21-modified adipose-derived mesenchymal stem cell (ADSC) exosomes promote wound healing. ADSCs overexpressing FGF21 were established using genetic engineering, and FGF21-enriched exosomes (Exo@FGF21) were isolated and characterized.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse + Human fibroblasts); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse + Human fibroblasts
Journal	Cellular signalling
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cellsig.2026.112742 · PMID 42551612

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	FGF21-modified ADSC exosomes
Target	AMPK/mTOR
Model	Mouse + Human (fibroblasts in vitro)
Effect	Promotes wound healing via fibroblast glycolysis, with AMPK activated and mTOR signaling suppressed

In the Atlas

Cite this paper

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Chen, K., Chen, X., Wen, C., Chen, W., Liao, Z., Chen, Y., & Li, L. (2026). FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling. Cellular signalling. https://doi.org/10.1016/j.cellsig.2026.112742

@article{CHEN2026,
  author       = {Chen, K. and Chen, X. and Wen, C. and Chen, W. and Liao, Z. and Chen, Y. and Li, L.},
  title        = {{FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling}},
  journal      = {Cellular signalling},
  year         = {2026},
  doi          = {10.1016/j.cellsig.2026.112742},
  note         = {PMID: 42551612},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CHEN2026) [Data set]. https://mtor-atlas.org/study/CHEN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CHEN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CHEN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CHEN2026/},
  doi          = {10.5281/zenodo.22059963}
}

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