Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway.

Forsythoside A (FTA), the primary bioactive component of Forsythiae Fructus, exhibits anti-inflammatory and antioxidant activity. Hypertensive nephropathy (HN) models were established in C57BL/6 mice and NRK-52E cells using Ang II. FTA mitigated Ang II-induced renal injury by reducing renal dysfunction markers (Cr, BUN, Alb/Cr), restoring renal tissue architecture and decreasing inflammatory markers, without exerting antihypertensive effects. RNA sequencing revealed associations with mTOR and ASCL1.

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Cui, X., et al. (2026). Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2026.122346

@article{CUI2026,
  author       = {Cui, X. and Yang, D. and Zhang, Z. and others},
  title        = {{Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway}},
  journal      = {Journal of Ethnopharmacology},
  year         = {2026},
  doi          = {10.1016/j.jep.2026.122346},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CUI2026) [Data set]. https://mtor-atlas.org/study/CUI2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CUI2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CUI2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CUI2026/},
  doi          = {10.5281/zenodo.22059963}
}