Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway.

Cui X, Yang D, Zhang Z, Wang C, Li H, Sun J, Zhang T, Wang M · 2026 · Journal of Ethnopharmacology · Atlas ID CUI2026

What this study shows

Forsythoside A binds ASCL1 and blocks the downstream CCNB1/mTOR axis, promoting mitophagy and suppressing ferroptosis to protect against Ang II-induced hypertensive nephropathy in mice — without lowering blood pressure.

Abstract

ShowHide

Forsythoside A (FTA), the primary bioactive component of Forsythiae Fructus, exhibits anti-inflammatory and antioxidant activity. Hypertensive nephropathy (HN) models were established in C57BL/6 mice and NRK-52E cells using Ang II. FTA mitigated Ang II-induced renal injury by reducing renal dysfunction markers (Cr, BUN, Alb/Cr), restoring renal tissue architecture and decreasing inflammatory markers, without exerting antihypertensive effects. RNA sequencing revealed associations with mTOR and ASCL1.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: C57BL/6 mouse; NRK-52E rat kidney cells); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	C57BL/6 mouse; NRK-52E rat kidney cells
Journal	Journal of Ethnopharmacology
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.jep.2026.122346 · PMID 42665168

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Forsythoside A
Target	ASCL1-CCNB1/mTOR; mitophagy; ferroptosis
Model	Mouse; rat kidney epithelial cells
Effect	Reduced renal dysfunction markers and inflammation; increased mitophagy, decreased ferroptosis

In the Atlas

Cite this paper

ShowHide

Cui, X., Yang, D., Zhang, Z., Wang, C., Li, H., Sun, J., Zhang, T., & Wang, M. (2026). Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2026.122346

@article{CUI2026,
  author       = {Cui, X. and Yang, D. and Zhang, Z. and Wang, C. and Li, H. and Sun, J. and Zhang, T. and Wang, M.},
  title        = {{Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway}},
  journal      = {Journal of Ethnopharmacology},
  year         = {2026},
  doi          = {10.1016/j.jep.2026.122346},
  note         = {PMID: 42665168},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CUI2026) [Data set]. https://mtor-atlas.org/study/CUI2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CUI2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CUI2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CUI2026/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?