Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 E5, E6, and E7 oncogene expression in breast cancer.

de Oliveira Isídio BE, Fontes PHB, da Silva GRP, Leão SL, de França São Marcos B, Simões IS, Barros EFG, Lussón DB, de Araujo GV, de Farias ID, de Melo KMTB, …, de Freitas AC · 2026 · Exploration of targeted anti-tumor therapy · Atlas ID DEOLIVEIRA2026

What this study shows

In breast tumour tissue (48 of 92 patients with usable RNA), HPV16 oncogene expression was associated with higher PI3K and lower mTOR transcript levels. The design is correlational and measures mRNA only, so it does not show that the virus activates the mTOR pathway.

Abstract

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Breast cancer is the most prevalent malignant tumor among women. Human papillomavirus (HPV) has been detected in breast tumors since the 1990s, and beyond its oncogenic potential, therapy resistance driven by viral immune evasion in non-anogenital tumors, such as oropharyngeal cancers, highlights the need to investigate viral activity in breast tissues. Among high-risk HPV types, HPV16 is one of the most prevalent and exhibits the highest carcinogenic potential.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human (clinical samples, FFPE tissue)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Human (clinical samples, FFPE tissue)
Journal	Exploration of targeted anti-tumor therapy
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.37349/etat.2026.1002391 · PMID 42558973 · Free full text (PMC13439120)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	HPV16 oncogene expression
Target	PI3K/AKT/mTOR
Model	Human
Effect	HPV-positive tumours: PI3K mRNA higher, mTOR mRNA lower (association)

In the Atlas

Cite this paper

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de Oliveira Isídio, B. E., Fontes, P. H. B., da Silva, G. R. P., Leão, S. L., de França São Marcos, B., Simões, I. S., Barros, E. F. G., Lussón, D. B., de Araujo, G. V., de Farias, I. D., de Melo KMTB, de Queiroz, N. L., da Silva, S. M. S., Santos, V. E. P., & de Freitas, A. C. (2026). Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 E5, E6, and E7 oncogene expression in breast cancer. Exploration of targeted anti-tumor therapy. https://doi.org/10.37349/etat.2026.1002391

@article{DEOLIVEIRA2026,
  author       = {de Oliveira Isídio, B. E. and Fontes, P. H. B. and da Silva, G. R. P. and Leão, S. L. and de França São Marcos, B. and Simões, I. S. and Barros, E. F. G. and Lussón, D. B. and de Araujo, G. V. and de Farias, I. D. and de Melo KMTB and de Queiroz, N. L. and da Silva, S. M. S. and Santos, V. E. P. and de Freitas, A. C.},
  title        = {{Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 E5, E6, and E7 oncogene expression in breast cancer}},
  journal      = {Exploration of targeted anti-tumor therapy},
  year         = {2026},
  doi          = {10.37349/etat.2026.1002391},
  note         = {PMID: 42558973},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEOLIVEIRA2026) [Data set]. https://mtor-atlas.org/study/DEOLIVEIRA2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEOLIVEIRA2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEOLIVEIRA2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEOLIVEIRA2026/},
  doi          = {10.5281/zenodo.22059963}
}

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