Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 oncogene expression in breast cancer.

de Oliveira Isidio BE, Fontes PHB, da Silva GRP, Leao SL, de Franca Sao Marcos B et al. · 2026 · Exploration of targeted anti-tumor therapy · Atlas ID DEOLIVEIRA2026

What this study shows

HPV16 oncogene expression in breast tumor tissue from 92 patients transcriptionally upregulates PI3K/AKT/mTOR pathway components, suggesting a viral mechanism contributing to mTOR pathway activation in breast cancer.

Abstract

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Breast cancer is the most prevalent malignant tumor among women. Human papillomavirus (HPV) has been detected in breast tumors since the 1990s, and beyond its oncogenic potential, therapy resistance driven by viral immune evasion in non-anogenital tumors highlights the need to investigate viral activity in breast tissues. Among high-risk HPV types, HPV16 is one of the most prevalent and exhibits the highest carcinogenic potential. This study aimed to evaluate the expression of HPV16 oncogenes and the modulation of the PI3K/AKT/mTOR signaling pathway associated with viral activity.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human (clinical samples, FFPE tissue)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Human (clinical samples, FFPE tissue)
Journal	Exploration of targeted anti-tumor therapy
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.37349/etat.2026.1002391 · PMID 42558973 · Free full text (PMC13439120)

Extracted findings

Intervention	HPV16 oncogene expression
Target	PI3K/AKT/mTOR
Model	Human
Effect	Upregulates PI3K/AKT/mTOR pathway transcription in breast cancer

Cite this paper

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de Oliveira Isidio, B. E., et al. (2026). Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 oncogene expression in breast cancer. Exploration of targeted anti-tumor therapy. https://doi.org/10.37349/etat.2026.1002391

@article{DEOLIVEIRA2026,
  author       = {de Oliveira Isidio, B. E. and Fontes, P. H. B. and da Silva, G. R. P. and Leao, S. L. and de Franca Sao Marcos, B. and others},
  title        = {{Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 oncogene expression in breast cancer}},
  journal      = {Exploration of targeted anti-tumor therapy},
  year         = {2026},
  doi          = {10.37349/etat.2026.1002391},
  note         = {PMID: 42558973},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEOLIVEIRA2026) [Data set]. https://mtor-atlas.org/study/DEOLIVEIRA2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEOLIVEIRA2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEOLIVEIRA2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEOLIVEIRA2026/},
  doi          = {10.5281/zenodo.22059963}
}