Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions

Lai M, Xu F, Xu Y, Mironenkov A, Jin Y, Zhang S, Pan J, Li M, Deng B, Zhu JK, Lyu YX · 2026 · Biogerontology · Atlas ID LAI2026

What this study shows

In 24 young Beagles given a 90-day course of rapamycin, the SGLT2 inhibitor canagliflozin, or dietary restriction, rapamycin produced the broadest shift in blood cytokines of the three, while a separate cross-sectional cohort of 80 Beagles aged 1-11 showed that immune aging in dogs is non-linear and sex-stratified rather than a steady decline. Dogs are an increasingly used translational model for geroscience because of their size and lifespan diversity, so this adds a rare canine data point to the rapamycin-immune-aging picture; the authors flag the intervention findings as exploratory given small group sizes and endpoint-only measurements.

Abstract

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Canine models are invaluable for translational geroscience, but natural sex-associated immune aging remains under investigated. Here, we characterize the age-associated hematologic and serum cytokine profiles in a controlled cross-sectional cohort of 80 intact laboratory Beagles spanning 1 to 11 years of age. Canine immune aging is heterogeneous and non-linear. While several absolute leukocyte counts declined with age before rising again in geriatric dogs, serum cytokines exhibited distinct, sex-stratified patterns.

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At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Dog (intact laboratory Beagles: 80-dog cross-sectional cohort ages 1-11; 24 young dogs for a 90-day intervention arm)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Dog (intact laboratory Beagles: 80-dog cross-sectional cohort ages 1-11; 24 young dogs for a 90-day intervention arm)
Journal	Biogerontology
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s10522-026-10518-w · PMID 42837017

In the Atlas

Cite this paper

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Lai, M., Xu, F., Xu, Y., Mironenkov, A., Jin, Y., Zhang, S., Pan, J., Li, M., Deng, B., Zhu, J. K., & Lyu, Y. X. (2026). Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions. Biogerontology. https://doi.org/10.1007/s10522-026-10518-w

@article{LAI2026,
  author       = {Lai, M. and Xu, F. and Xu, Y. and Mironenkov, A. and Jin, Y. and Zhang, S. and Pan, J. and Li, M. and Deng, B. and Zhu, J. K. and Lyu, Y. X.},
  title        = {{Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions}},
  journal      = {Biogerontology},
  year         = {2026},
  doi          = {10.1007/s10522-026-10518-w},
  note         = {PMID: 42837017},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LAI2026) [Data set]. https://mtor-atlas.org/study/LAI2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LAI2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LAI2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LAI2026/},
  doi          = {10.5281/zenodo.22059963}
}

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