Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH · 2017 · Molecular cell · Atlas ID SUX2017

What this study shows

Hybrid structural model of the RagA/C-Ragulator mTORC1 activation complex.

Abstract

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The lysosomal membrane is the locus for sensing cellular nutrient levels, which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex. The crystal structure of the five-subunit human Ragulator at 1.4 A resolution was determined. Lamtor1 wraps around the other four subunits to stabilize the assembly. The Lamtor2:Lamtor3 dimer stacks upon Lamtor4:Lamtor5 to create a platform for Rag binding. Hydrogen-deuterium exchange was used to map the Rag binding site to the outer face of the Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Hybrid structure) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Hybrid structure
Journal	Molecular cell
Year	2017
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.molcel.2017.10.016 · PMID 29107538 · Free full text (PMC5722659)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Structural (crystal/hybrid)
Target	Rag GTPases / Ragulator (Lamtor1-5) / mTORC1
Model	Hybrid structure
Effect	Structure of the RagA/C-Ragulator activation complex; Lamtor1 wraps the subunits to form the Rag-binding platform

In the Atlas

Cite this paper

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Su, M. Y., Morris, K. L., Kim, D. J., Fu, Y., Lawrence, R., Stjepanovic, G., Zoncu, R., & Hurley, J. H. (2017). Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Molecular cell. https://doi.org/10.1016/j.molcel.2017.10.016

@article{SUX2017,
  author       = {Su, M. Y. and Morris, K. L. and Kim, D. J. and Fu, Y. and Lawrence, R. and Stjepanovic, G. and Zoncu, R. and Hurley, J. H.},
  title        = {{Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex}},
  journal      = {Molecular cell},
  year         = {2017},
  doi          = {10.1016/j.molcel.2017.10.016},
  note         = {PMID: 29107538},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SUX2017) [Data set]. https://mtor-atlas.org/study/SUX2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SUX2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SUX2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SUX2017/},
  doi          = {10.5281/zenodo.22059963}
}

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