Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

The lysosomal membrane is the locus for sensing cellular nutrient levels, which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex. The crystal structure of the five-subunit human Ragulator at 1.4 A resolution was determined. Lamtor1 wraps around the other four subunits to stabilize the assembly. The Lamtor2:Lamtor3 dimer stacks upon Lamtor4:Lamtor5 to create a platform for Rag binding. Hydrogen-deuterium exchange was used to map the Rag binding site to the outer face of the Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.

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Su, M. Y., et al. (2017). Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Molecular cell. https://doi.org/10.1016/j.molcel.2017.10.016

@article{SUX2017,
  author       = {Su, M. Y. and Hurley, J. H. and others},
  title        = {{Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex}},
  journal      = {Molecular cell},
  year         = {2017},
  doi          = {10.1016/j.molcel.2017.10.016},
  note         = {PMID: 29107538},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SUX2017) [Data set]. https://mtor-atlas.org/study/SUX2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SUX2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SUX2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SUX2017/},
  doi          = {10.5281/zenodo.22059963}
}