The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM · 2012 · Science signaling · Atlas ID ROC2012

What this study shows

mTORC1 phosphorylates TFEB to control lysosomal and autophagy gene transcription.

Abstract

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Lysosomes are the major cellular site for clearance of defective organelles and digestion of internalized material. Demand on lysosomal capacity can vary greatly, and lysosomal function must be adjusted to maintain cellular homeostasis. Here, we identified an interaction between the lysosome-localized mechanistic target of rapamycin complex 1 (mTORC1) and the transcription factor TFEB, which promotes lysosome biogenesis.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Science signaling
Year	2012
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1126/scisignal.2002790 · PMID 22692423 · Free full text (PMC3437338)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/pharmacologic (mTORC1/TFEB)
Target	mTORC1 / TFEB
Model	Mammalian cells
Effect	mTORC1 controls TFEB to transcriptionally regulate lysosome biogenesis and homeostasis

In the Atlas

Links in the pathway map

Supports mTORC1 inhibits TFEB
Supports TFEB activates Autophagy
Supports TFEB activates Lysosomal biogenesis

Cite this paper

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Roczniak-Ferguson, A., Petit, C. S., Froehlich, F., Qian, S., Ky, J., Angarola, B., Walther, T. C., & Ferguson, S. M. (2012). The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Science signaling. https://doi.org/10.1126/scisignal.2002790

@article{ROC2012,
  author       = {Roczniak-Ferguson, A. and Petit, C. S. and Froehlich, F. and Qian, S. and Ky, J. and Angarola, B. and Walther, T. C. and Ferguson, S. M.},
  title        = {{The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis}},
  journal      = {Science signaling},
  year         = {2012},
  doi          = {10.1126/scisignal.2002790},
  note         = {PMID: 22692423},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ROC2012) [Data set]. https://mtor-atlas.org/study/ROC2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ROC2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ROC2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ROC2012/},
  doi          = {10.5281/zenodo.22059963}
}

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