The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

Lysosomes are the major cellular site for clearance of defective organelles and digestion of internalized material. Demand on lysosomal capacity can vary greatly, and lysosomal function must be adjusted to maintain cellular homeostasis. Here, we identified an interaction between the lysosome-localized mechanistic target of rapamycin complex 1 (mTORC1) and the transcription factor TFEB, which promotes lysosome biogenesis.

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Roczniak-Ferguson, A., et al. (2012). The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Science signaling. https://doi.org/10.1126/scisignal.2002790

@article{ROC2012,
  author       = {Roczniak-Ferguson, A. and Ferguson, S. M. and others},
  title        = {{The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis}},
  journal      = {Science signaling},
  year         = {2012},
  doi          = {10.1126/scisignal.2002790},
  note         = {PMID: 22692423},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ROC2012) [Data set]. https://mtor-atlas.org/study/ROC2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ROC2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ROC2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ROC2012/},
  doi          = {10.5281/zenodo.22059963}
}