Pathway link TFEB-LYSOBIO
TFEB Lysosomal biogenesis
TFEB activates Lysosomal biogenesis.
In the nucleus, TFEB switches on a whole gene package for cleanup and for building new lysosomes.
The conditions it holds under
Transcriptional output measured as gene expression and lysosomal markers; how much the compartment actually expands varies with cell type and starvation depth.
- Time it takes
- hours
- Step
- direct (one molecule acts on the other)
- Measured in
- human cells, mouse cells
- Where in the cell
- nucleus
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2011 | M | TFEB links autophagy to lysosomal biogenesisSET2011 Showed that TFEB drives a coordinated autophagy and lysosomal gene programme during starvation. In this paper TFEB was regulated by ERK2 phosphorylation; its control by mTORC1 at the lysosome was established in later work (SET2012). |
| 2012 | M | The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasisROC2012 mTORC1 phosphorylates TFEB to control lysosomal and autophagy gene transcription. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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