Oliver's mTOR Atlas Evidence Platform
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Pathway link TFEB-AUTOPHAGY

TFEB Autophagy

TFEB activates Autophagy.

Once inside the nucleus, TFEB switches on a whole set of genes for cleanup and for building new lysosomes.

In the nucleus TFEB switches on a whole gene programme for autophagy and for building new lysosomes - the cell's recycling capacity, not just a single step.

The conditions it holds under

Human and mouse cell studies (SET2011, ROC2012, SET2012). The gene programme is shown in cells; its contribution to autophagy in living tissue and in people is not measured here.

Same flux caveat as ULK1-AUTOPHAGY: TFEB target-gene induction (more lysosomes, more autophagy machinery transcribed) is not itself proof that degradative flux increased - it raises capacity, which still needs to be confirmed with a flux readout rather than assumed from expression alone.

Time it takes
hours
Step
direct (one molecule acts on the other)
Measured in
mammalian cells
Where in the cell
nucleus
Reaches people?
plausible in people, not shown directly
How settled
settled in the literature

Studies behind it

YearEvidenceStudy
2011 M TFEB links autophagy to lysosomal biogenesisSET2011 Showed that TFEB drives a coordinated autophagy and lysosomal gene programme during starvation. In this paper TFEB was regulated by ERK2 phosphorylation; its control by mTORC1 at the lysosome was established in later work (SET2012).
2012 M The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasisROC2012 mTORC1 phosphorylates TFEB to control lysosomal and autophagy gene transcription.
2012 M A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBSET2012 A lysosome-to-nucleus mechanism uses mTOR-dependent TFEB phosphorylation to sense lysosomal state.

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by
No researcher outside the project has checked this link yet.
Curator sign-off
Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
Curated by
Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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