{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "TFEB-AUTOPHAGY",
  "claim": "TFEB activates Autophagy",
  "source": {
   "name": "TFEB",
   "entity": "tfeb"
  },
  "target": {
   "name": "Autophagy",
   "entity": "autophagy"
  },
  "effect": "activates",
  "type": "transcriptional",
  "directness": "direct",
  "timescale": "hours",
  "compartment": "nucleus",
  "map_band": "nucleus",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "In the nucleus TFEB switches on a whole gene programme for autophagy and for building new lysosomes - the cell's recycling capacity, not just a single step.",
  "mechanism_beginner": "Once inside the nucleus, TFEB switches on a whole set of genes for cleanup and for building new lysosomes.",
  "context": "Same flux caveat as ULK1-AUTOPHAGY: TFEB target-gene induction (more lysosomes, more autophagy machinery transcribed) is not itself proof that degradative flux increased - it raises capacity, which still needs to be confirmed with a flux readout rather than assumed from expression alone.",
  "boundary": "Human and mouse cell studies (SET2011, ROC2012, SET2012). The gene programme is shown in cells; its contribution to autophagy in living tissue and in people is not measured here.",
  "boundary_tags": [],
  "conflict": null,
  "note": "The transcriptional arm of autophagy, distinct from the fast ULK1 arm.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "SET2011",
    "ROC2012",
    "SET2012"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/TFEB-AUTOPHAGY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/TFEB-AUTOPHAGY.json"
 }
}