Oliver's mTOR Atlas Evidence Platform
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Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma

Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S · 2013 · Cancer Research · Atlas ID OKA2013

What this study shows

In mouse kidney tumours, active phosphorylated mTOR and total mTOR protein followed a 24-hour rhythm, set by the clock through the ubiquitin ligase Fbxw7. Giving everolimus when mTOR was high improved survival compared with other dosing times. Same drug, same dose - the clock time of dosing changed the outcome.

Abstract

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Circadian clock systems regulate many biologic functions, including cell division and hormone secretion in mammals. In this study, we explored the effects of circadian control on the pivot cell growth regulatory mTOR, the activity of which is deregulated in tumor cells compared with normal cells. Specifically, we investigated whether the antitumor effect of an mTOR inhibitor could be improved by changing its dosing schedule in RenCa tumor-bearing mice.

Read the full abstract on PubMed →

At a glance

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Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: RenCa tumour-bearing mice; NIH 3T3 cells); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model systemRenCa tumour-bearing mice; NIH 3T3 cells
JournalCancer Research
Year2013
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.1158/0008-5472.CAN-12-3241 · PMID 24253377

Where this study fits

How this study connects to the pathway map, open questions, people and other studies in the Atlas.

People in the Atlas

  • Hiroyuki Okazaki first author · 1 study in the Atlas

    Pharmacologist at Daiichi University of Pharmacy in Fukuoka who studies how the body clock sets the daily rhythm of mTOR in tumours and how to time cancer drugs to match it

  • Shigehiro Ohdo last author · 1 study in the Atlas

    Works on the body clock and drug timing (chronopharmacology), including how circadian rhythms control mTOR in cancer cells.

More: 8 other authors

No profile yet: Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S

Related studies

More related studies

All 125 studies on mTOR

Topics

Renal cell carcinoma (RCC)mTOREverolimus

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

InterventionEverolimus dosed at different times of day
TargetmTOR; Fbxw7; DBP
ModelMouse
EffectDosing everolimus at the mTOR peak improved survival of tumour-bearing mice

Cite this paper

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Okazaki, H., Matsunaga, N., Fujioka, T., Okazaki, F., Akagawa, Y., Tsurudome, Y., Ono, M., Kuwano, M., Koyanagi, S., & Ohdo, S. (2013). Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-12-3241

@article{OKA2013,
  author       = {Okazaki, H. and Matsunaga, N. and Fujioka, T. and Okazaki, F. and Akagawa, Y. and Tsurudome, Y. and Ono, M. and Kuwano, M. and Koyanagi, S. and Ohdo, S.},
  title        = {{Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma}},
  journal      = {Cancer Research},
  year         = {2013},
  doi          = {10.1158/0008-5472.CAN-12-3241},
  note         = {PMID: 24253377},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record OKA2013) [Data set]. https://mtor-atlas.org/study/OKA2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_OKA2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record OKA2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/OKA2013/},
  doi          = {10.5281/zenodo.22059963}
}
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