Shigehiro Ohdo
Works on the body clock and drug timing (chronopharmacology), including how circadian rhythms control mTOR in cancer cells.
Specially Appointed Professor, Faculty of Pharmaceutical Sciences, Kyushu University
Faculty of Pharmaceutical Sciences, Kyushu University (Fukuoka, Japan) ↗
Shigehiro Ohdo is a pharmaceutical scientist at Kyushu University in Fukuoka, Japan. His university profile describes his aim as new chronotherapy based on the molecular clock: timing drug doses to the body's daily rhythms so they work better and cause fewer side effects.
In the 2013 Cancer Research paper in the Atlas, he was the last author. The team studied renal cell carcinoma, a kidney cancer, and asked how the circadian clock controls mTOR. They reported that the clock regulates mTOR through the ubiquitin system, the cell's protein tagging and disposal machinery.
For a student, the link is simple: the activity of mTOR is not constant over a day, and this work asks whether that rhythm matters for how cancers grow and how mTOR drugs might be timed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2013 | A | Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma OKA2013 Last author of the Cancer Research study describing circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Shigehiro Ohdo.
ShowHide
- Hiroyuki Okazaki Pharmacologist at Daiichi University of Pharmacy in Fukuoka who studies how the body clock sets the daily rhythm of mTOR in tumours and how to time cancer drugs to match it
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.