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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Garcia-Martinez JM, Alessi DR et al. · 2008 · The Biochemical journal · Atlas ID GAR2008

What this study shows

mTORC2 controls hydrophobic-motif phosphorylation and activity of SGK1 in addition to Akt.

Abstract

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SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein kinase C) family of protein kinases and is activated by agonists including growth factors. SGK1 regulates diverse effects of extracellular agonists by phosphorylating regulatory proteins that control cellular processes such as ion transport and growth.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalThe Biochemical journal
Year2008
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1042/BJ20081668 · PMID 18925875

Extracted findings

InterventionGenetic/biochemical (mTORC2/SGK1)
TargetmTORC2 / SGK1
ModelMammalian cells
EffectmTORC2 controls the hydrophobic-motif phosphorylation and activation of SGK1

Cite this paper

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Garcia-Martinez, J. M., et al. (2008). mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). The Biochemical journal. https://doi.org/10.1042/BJ20081668

@article{GAR2008,
  author       = {Garcia-Martinez, J. M. and Alessi, D. R. and others},
  title        = {{mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)}},
  journal      = {The Biochemical journal},
  year         = {2008},
  doi          = {10.1042/BJ20081668},
  note         = {PMID: 18925875},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GAR2008) [Data set]. https://mtor-atlas.org/study/GAR2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAR2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAR2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAR2008/},
  doi          = {10.5281/zenodo.22059963}
}