mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Garcia-Martinez JM, Alessi DR · 2008 · The Biochemical journal · Atlas ID GAR2008

What this study shows

mTORC2 controls hydrophobic-motif phosphorylation and activity of SGK1 in addition to Akt.

Abstract

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SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein kinase C) family of protein kinases and is activated by agonists including growth factors. SGK1 regulates diverse effects of extracellular agonists by phosphorylating regulatory proteins that control cellular processes such as ion transport and growth.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	The Biochemical journal
Year	2008
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1042/BJ20081668 · PMID 18925875

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/biochemical (mTORC2/SGK1)
Target	mTORC2 / SGK1
Model	Mammalian cells
Effect	mTORC2 controls the hydrophobic-motif phosphorylation and activation of SGK1

In the Atlas

Links in the pathway map

Supports mTORC2 activates SGK1

Cite this paper

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Garcia-Martinez, J. M., & Alessi, D. R. (2008). mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). The Biochemical journal. https://doi.org/10.1042/BJ20081668

@article{GAR2008,
  author       = {Garcia-Martinez, J. M. and Alessi, D. R.},
  title        = {{mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)}},
  journal      = {The Biochemical journal},
  year         = {2008},
  doi          = {10.1042/BJ20081668},
  note         = {PMID: 18925875},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GAR2008) [Data set]. https://mtor-atlas.org/study/GAR2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAR2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAR2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAR2008/},
  doi          = {10.5281/zenodo.22059963}
}

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