Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments activate different mTORC1 complexes, which may have distinct drug sensitivities and functions.

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Goberdhan, D. C., Wilson, C., & Harris, A. L. (2016). Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Cell metabolism. https://doi.org/10.1016/j.cmet.2016.03.013

@article{GOB2016,
  author       = {Goberdhan, D. C. and Wilson, C. and Harris, A. L.},
  title        = {{Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot}},
  journal      = {Cell metabolism},
  year         = {2016},
  doi          = {10.1016/j.cmet.2016.03.013},
  note         = {PMID: 27076075},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GOB2016) [Data set]. https://mtor-atlas.org/study/GOB2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GOB2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GOB2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GOB2016/},
  doi          = {10.5281/zenodo.22059963}
}