Mitochondrial dysfunction

Condition · 1 studies in the Atlas

Loss of mitochondrial function, relayed to mTORC1 by AMPK and the HRI stress pathway.

Power plants in trouble. Power plants in trouble.

Genome-wide CRISPR screens (CON2021) show the relay is multitiered rather than single-channel: AMPK carries the energetic signal and heme-regulated inhibitor (HRI) carries a mitochondrial stress signal through the integrated stress response. mTORC1 therefore reads mitochondrial state through at least two independent routes.

TL;DR. Mitochondrial dysfunction appears in 1 curated study in Oliver's mTOR Atlas: 1 at the molecular level (cells, biochemistry, structure). No study in people is recorded for it in the Atlas yet. It has 1 interaction in the curated pathway model.

In the pathway model

1 interaction in the curated mTOR pathway model. Each row is a claim with the evidence behind it; the evidence code is the kind of study, not its quality.

Interaction	Mechanism	Evidence	Studies
Mitochondrial dysfunction inhibits mTORC1 mechanism: signal-relay · this link in full · on the map table	When mitochondria – the cell's power plants – are damaged, at least two separate alarm signals reach mTORC1 to shut it down. Genome-wide CRISPR screens identify at least two parallel relays carrying mitochondrial dysfunction to mTORC1: AMPK, and the heme-regulated inhibitor HRI acting through the integrated stress response. Genome-wide CRISPR screens identify at least two parallel relays carrying mitochondrial dysfunction to mTORC1: AMPK, and the heme-regulated inhibitor HRI acting through the integrated stress response. Holds under: CRISPR screening in cell lines; the relative weight of the AMPK and HRI arms in tissue is untested. plausible in people, not shown directly · emerging, few independent studies	M	CON2021

Evidence at a glance

Evidence	What it means	Studies
M	Molecular — cells, biochemistry, structure	1

No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.

Studies

Year	Evidence	Study
2021	M	Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction CON2021 Genome-wide CRISPR screens reveal AMPK and HRI relay mitochondrial dysfunction to mTORC1.

Cite this page

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Barton, O. (2026). Mitochondrial dysfunction [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/condition/mitochondrial-dysfunction/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_condition_mitochondrial_dysfunction,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: Mitochondrial dysfunction},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/condition/mitochondrial-dysfunction/},
  doi          = {10.5281/zenodo.22059963}
}

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