Pathway link MITODYS-MTORC1

Mitochondrial dysfunction ⊣ mTORC1

Mitochondrial dysfunction inhibits mTORC1.

When mitochondria – the cell's power plants – are damaged, at least two separate alarm signals reach mTORC1 to shut it down.

Genome-wide CRISPR screens identify at least two parallel relays carrying mitochondrial dysfunction to mTORC1: AMPK, and the heme-regulated inhibitor HRI acting through the integrated stress response.

The conditions it holds under

CRISPR screening in cell lines; the relative weight of the AMPK and HRI arms in tissue is untested.

Time it takes

hours

Step

indirect (through steps not drawn here)

Measured in

human cells

Where in the cell

cytosol

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

← The whole pathway · This link as JSON