A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome

The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we show that transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is phosphorylated by mTORC1 via a substrate-specific mechanism that is mediated by Rag GTPases.

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Napolitano, G., et al. (2020). A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome. Nature. https://doi.org/10.1038/s41586-020-2444-0

@article{NAP2020,
  author       = {Napolitano, G. and Ballabio, A. and others},
  title        = {{A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome}},
  journal      = {Nature},
  year         = {2020},
  doi          = {10.1038/s41586-020-2444-0},
  note         = {PMID: 32612235},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record NAP2020) [Data set]. https://mtor-atlas.org/study/NAP2020/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_NAP2020,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record NAP2020},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/NAP2020/},
  doi          = {10.5281/zenodo.22059963}
}