Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

PTEN (phosphatase and tensin homolog deleted on chromosome ten) is a lipid phosphatase that counteracts the function of phosphatidylinositol-3 kinase (PI3K). Loss of function of PTEN results in constitutive activation of AKT and downstream effectors and correlates with many human cancers, as well as various brain disorders, including macrocephaly, seizures, Lhermitte-Duclos disease, and autism. We previously generated a conditional Pten knock-out mouse line with Pten loss in limited postmitotic neurons in the cortex and hippocampus.

Read the full abstract on PubMed →

Zhou, J., et al. (2009). Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. The Journal of neuroscience. https://doi.org/10.1523/JNEUROSCI.5685-08.2009

@article{ZHO2009,
  author       = {Zhou, J. and Parada, L. F. and others},
  title        = {{Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice}},
  journal      = {The Journal of neuroscience},
  year         = {2009},
  doi          = {10.1523/JNEUROSCI.5685-08.2009},
  note         = {PMID: 19211884},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZHO2009) [Data set]. https://mtor-atlas.org/study/ZHO2009/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZHO2009,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZHO2009},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZHO2009/},
  doi          = {10.5281/zenodo.22059963}
}