Luis F. Parada
Uses genetically engineered mouse models to study nervous system tumours such as glioblastoma and neurofibromatosis-related tumours, and the brain effects of PTEN loss.
Memorial Sloan Kettering Cancer Center · Director, Brain Tumor Center; Albert C. Foster Chair · Member, National Academy of Sciences (2011)
Portrait: Memorial Sloan Kettering Cancer Center
Luis Parada is a neuroscientist and cancer biologist at Memorial Sloan Kettering Cancer Center, where he directs the Brain Tumor Center. His lab builds mouse models of nervous system tumours, including glioblastoma, neurofibromas and malignant peripheral nerve sheath tumours. When the Atlas study was done in 2009 his lab was at UT Southwestern Medical Center in Dallas.
The 2009 paper in the Atlas, with Jing Zhou as first author, used mice that lack the PTEN gene in some neurons of the cortex and hippocampus. PTEN normally holds back the PI3K and AKT pathway upstream of mTOR, so these mice have overactive mTORC1, enlarged neurons, large brains and behaviours that resemble some features of autism.
Rapamycin, an mTORC1 inhibitor, both prevented and reversed the neuron enlargement and improved some of the abnormal behaviours. The work pointed to mTORC1 as a drug target for PTEN-related brain disorders. It was done in mice.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2009 | A | Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice ZHO2009 Rapamycin prevented and reversed neuronal hypertrophy and improved some abnormal behaviours in neural-specific Pten knock-out mice; Parada was senior author. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Luis F. Parada.
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- Jing Zhou Researcher in Luis Parada's lab whose work includes the 2009 study showing that rapamycin prevents and reverses brain abnormalities in neural Pten-knockout mice
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