Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Garcia-Martinez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM, Alessi DR · 2009 · The Biochemical journal · Atlas ID GAR2009

What this study shows

Ku-0063794 is a specific ATP-competitive mTOR inhibitor blocking mTORC1 and mTORC2.

Abstract

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mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (serum and glucocorticoid protein kinase). mTORC1 phosphorylates the hydrophobic motif of S6K, whereas mTORC2 phosphorylates the hydrophobic motif of Akt and SGK.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: In vitro; cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	In vitro; cells
Journal	The Biochemical journal
Year	2009
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1042/BJ20090489 · PMID 19402821 · Free full text (PMC2708931)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Ku-0063794 (ATP-competitive mTOR inhibitor)
Target	mTORC1 & mTORC2
Model	In vitro; cells
Effect	Ku-0063794 is a specific mTOR inhibitor blocking both complexes (Akt/S6K/SGK signaling)

In the Atlas

Links in the pathway map

Supports ATP-competitive mTOR inhibitors inhibits mTORC1
Supports ATP-competitive mTOR inhibitors inhibits mTORC2

Cite this paper

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Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M., & Alessi, D. R. (2009). Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). The Biochemical journal. https://doi.org/10.1042/BJ20090489

@article{GAR2009,
  author       = {Garcia-Martinez, J. M. and Moran, J. and Clarke, R. G. and Gray, A. and Cosulich, S. C. and Chresta, C. M. and Alessi, D. R.},
  title        = {{Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)}},
  journal      = {The Biochemical journal},
  year         = {2009},
  doi          = {10.1042/BJ20090489},
  note         = {PMID: 19402821},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GAR2009) [Data set]. https://mtor-atlas.org/study/GAR2009/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAR2009,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAR2009},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAR2009/},
  doi          = {10.5281/zenodo.22059963}
}

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