Oliver's mTOR Atlas Evidence Platform
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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Garcia-Martinez JM, Alessi DR et al. · 2009 · The Biochemical journal · Atlas ID GAR2009

What this study shows

Ku-0063794 is a specific ATP-competitive mTOR inhibitor blocking mTORC1 and mTORC2.

Abstract

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mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (serum and glucocorticoid protein kinase). mTORC1 phosphorylates the hydrophobic motif of S6K, whereas mTORC2 phosphorylates the hydrophobic motif of Akt and SGK.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: In vitro; cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemIn vitro; cells
JournalThe Biochemical journal
Year2009
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1042/BJ20090489 · PMID 19402821 · Free full text (PMC2708931)

Extracted findings

InterventionKu-0063794 (ATP-competitive mTOR inhibitor)
TargetmTORC1 & mTORC2
ModelIn vitro; cells
EffectKu-0063794 is a specific mTOR inhibitor blocking both complexes (Akt/S6K/SGK signaling)

Cite this paper

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Garcia-Martinez, J. M., et al. (2009). Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). The Biochemical journal. https://doi.org/10.1042/BJ20090489

@article{GAR2009,
  author       = {Garcia-Martinez, J. M. and Alessi, D. R. and others},
  title        = {{Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)}},
  journal      = {The Biochemical journal},
  year         = {2009},
  doi          = {10.1042/BJ20090489},
  note         = {PMID: 19402821},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record GAR2009) [Data set]. https://mtor-atlas.org/study/GAR2009/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAR2009,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAR2009},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAR2009/},
  doi          = {10.5281/zenodo.22059963}
}