Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu L, Lenardo MJ et al. · 2010 · Nature · Atlas ID YUX2010

What this study shows

Reactivation of mTOR terminates autophagy and drives autophagic lysosome reformation (ALR).

Abstract

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Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles are catabolized. During starvation, the protein TOR (target of rapamycin), a nutrient-responsive kinase, is inhibited, and this induces autophagy. In autophagy, double-membrane autophagosomes envelop and sequester intracellular components and then fuse with lysosomes to form autolysosomes, which degrade their contents to regenerate nutrients.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Nature
Year	2010
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1038/nature09076 · PMID 20526321 · Free full text (PMC2920749)

Extracted findings

Intervention	Genetic/pharmacologic (mTOR reactivation)
Target	mTOR / autophagic lysosome reformation
Model	Mammalian cells
Effect	Reactivation of mTOR terminates autophagy and drives reformation of lysosomes (ALR)

In the Atlas

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Cite this paper

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Yu, L., et al. (2010). Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. https://doi.org/10.1038/nature09076

@article{YUX2010,
  author       = {Yu, L. and Lenardo, M. J. and others},
  title        = {{Termination of autophagy and reformation of lysosomes regulated by mTOR}},
  journal      = {Nature},
  year         = {2010},
  doi          = {10.1038/nature09076},
  note         = {PMID: 20526321},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record YUX2010) [Data set]. https://mtor-atlas.org/study/YUX2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_YUX2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record YUX2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/YUX2010/},
  doi          = {10.5281/zenodo.22059963}
}