Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, …, Lenardo MJ · 2010 · Nature · Atlas ID YUX2010

What this study shows

Reactivation of mTOR terminates autophagy and drives autophagic lysosome reformation (ALR).

Abstract

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Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles are catabolized. During starvation, the protein TOR (target of rapamycin), a nutrient-responsive kinase, is inhibited, and this induces autophagy. In autophagy, double-membrane autophagosomes envelop and sequester intracellular components and then fuse with lysosomes to form autolysosomes, which degrade their contents to regenerate nutrients.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Nature
Year	2010
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nature09076 · PMID 20526321 · Free full text (PMC2920749)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/pharmacologic (mTOR reactivation)
Target	mTOR / autophagic lysosome reformation
Model	Mammalian cells
Effect	Reactivation of mTOR terminates autophagy and drives reformation of lysosomes (ALR)

In the Atlas

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Cite this paper

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Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., Hailey, D. W., Oorschot, V., Klumperman, J., Baehrecke, E. H., & Lenardo, M. J. (2010). Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. https://doi.org/10.1038/nature09076

@article{YUX2010,
  author       = {Yu, L. and McPhee, C. K. and Zheng, L. and Mardones, G. A. and Rong, Y. and Peng, J. and Mi, N. and Zhao, Y. and Liu, Z. and Wan, F. and Hailey, D. W. and Oorschot, V. and Klumperman, J. and Baehrecke, E. H. and Lenardo, M. J.},
  title        = {{Termination of autophagy and reformation of lysosomes regulated by mTOR}},
  journal      = {Nature},
  year         = {2010},
  doi          = {10.1038/nature09076},
  note         = {PMID: 20526321},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record YUX2010) [Data set]. https://mtor-atlas.org/study/YUX2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_YUX2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record YUX2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/YUX2010/},
  doi          = {10.5281/zenodo.22059963}
}

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