Michael J. Lenardo
Immunologist known for work on how immune cells die and are controlled; his lab also showed that mTOR reactivation ends autophagy and rebuilds lysosomes.
NIAID, NIH · Former Chief, Molecular Development of the Immune System Section (Senior Investigator from 1994) · National Academy of Sciences (2019)
Molecular Development of the Immune System Section, Laboratory of Immunology, NIAID, National Institutes of Health (Bethesda, Maryland, USA) ↗ Lab lineagetrained under David Baltimore →
Portrait: Wikimedia Commons
Michael Lenardo is an immunologist at the National Institute of Allergy and Infectious Diseases (NIAID) in the US National Institutes of Health. His NIAID profile says he set up an independent research unit there in 1989 and became a Senior Investigator and Section Chief in 1994. He trained at Johns Hopkins (BA), Washington University in St. Louis (MD) and, as a postdoctoral fellow, at the Whitehead Institute at MIT.
The 2010 Nature paper in the Atlas, with Li Yu as first author, looked at what happens to autophagy (the cell's recycling process) during long starvation. mTOR is switched off at first, which starts autophagy. After prolonged starvation, mTOR switches back on.
The reactivated mTOR stops autophagy and helps rebuild lysosomes, the cell's digestive compartments, from tubes that bud off the autolysosomes. This showed autophagy as a cycle that ends by restoring the lysosomes it used.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | M | Termination of autophagy and reformation of lysosomes regulated by mTOR YUX2010 Showed that mTOR is reactivated during prolonged starvation, terminating autophagy and driving autophagic lysosome reformation; Lenardo was senior author. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Michael J. Lenardo.
ShowHide
- Li Yu Cell biologist at Tsinghua University who, as a postdoc at the NIH, found how cells end autophagy and rebuild their lysosomes, and whose own group later discovered the migrasome, a new organelle left behind by migrating cells
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.