Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration.

Osteoarthritis (OA) is characterized by persistent inflammation, extracellular matrix degradation and impaired autophagy. IL-1β-stimulated primary mouse chondrocytes were used to evaluate Corilagin. Corilagin restored chondrocyte proliferation and increased Aggrecan, collagen II and SOX9 expression while reducing MMP3, MMP13, iNOS and COX2. Mechanistically, Corilagin inhibited PI3K/AKT/mTOR and NF-κB signaling, reduced p65 nuclear translocation and restored autophagic flux (increased Beclin-1 and LC3 II/I, decreased p62). 3-MA partially abolished these protective effects.

Read the full abstract →

Zhou, R., et al. (2026). Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration. International Immunopharmacology. https://doi.org/10.1016/j.intimp.2026.117342

@article{ZHOU2026B,
  author       = {Zhou, R. and Li Jie and Chen, S. and others},
  title        = {{Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration}},
  journal      = {International Immunopharmacology},
  year         = {2026},
  doi          = {10.1016/j.intimp.2026.117342},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZHOU2026B) [Data set]. https://mtor-atlas.org/study/ZHOU2026B/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZHOU2026B,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZHOU2026B},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZHOU2026B/},
  doi          = {10.5281/zenodo.22059963}
}